| Metformin administration and laparoscopic ovarian drilling improve ovarian response to clomiphene citrate (CC) in oligo-anovulatory CC-resistant women with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 16343096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy of clomiphene citrate (CC) administration for ovulation induction in CC-resistant oligo-ovulatory women with polycystic ovary syndrome (PCOS) after metformin treatment or laparoscopic ovarian drilling (LOD). Design Prospective controlled study. PATIENTS: Twenty-eight overweight oligo-amenorrhoeic women with PCOS who were still anovulatory after metformin administration (group A, n = 8) or LOD (group B, n = 20). METHODS: Treatment with CC 150 mg/day for 5 days from the third to the seventh day of a progesterone-induced uterine bleeding for 6 months. MEASUREMENTS: The ovulation, pregnancy, abortion and live-birth rates were evaluated in each group. RESULTS: The subjects of groups A and B were studied for a total of 36 and 74 cycles, respectively. At the end of the study, no differences in ovulation [11/36 (30.6%) vs. 23/74 (31.1%); P = 0.96], pregnancy [6/36 (16.7%) vs. 12/74 (16.2%); P = 0.95], abortion [2/6 (33.3%) vs. 5/12 (41.7%); P = 1.00] and the live-birth [4/6 (66.7%) vs. 7/12 (58.3%); P = 1.00] rates were observed between groups A and B. CONCLUSION: Metformin administration as well as LOD improves the effectiveness of CC for ovulation induction in overweight infertile CC-resistant women with PCOS. |
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Authors:
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Stefano Palomba; Francesco Orio; Angela Falbo; Tiziana Russo; Grande Caterina; Francesco Manguso; Achille Tolino; Annamaria Colao; Fulvio Zullo |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical endocrinology Volume: 63 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-13 Completed Date: 2006-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 631-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University Magna Graecia of Catanzaro, Italy. stefanopalomba@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clomiphene / therapeutic use* Combined Modality Therapy Female Fertility Agents, Female / therapeutic use* Humans Hypoglycemic Agents / therapeutic use* Laparoscopy Metformin / therapeutic use* Ovary / surgery* Ovulation Induction Polycystic Ovary Syndrome / drug therapy*, surgery Pregnancy Pregnancy Outcome Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 0/Hypoglycemic Agents; 657-24-9/Metformin; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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