| Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. | |
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MedLine Citation:
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PMID: 20134380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic metformin use results in vitamin B12 deficiency in 30% of patients. Exhaustion of vitamin B12 stores usually occurs after twelve to fifteen years of absolute vitamin B12 deficiency. Metformin has been available in the United States for approximately fifteen years. Vitamin B12 deficiency, which may present without anemia and as a peripheral neuropathy, is often misdiagnosed as diabetic neuropathy, although the clinical findings are usually different. Failure to diagnose the cause of the neuropathy will result in progression of central and/or peripheral neuronal damage which can be arrested but not reversed with vitamin B12 replacement. To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy. |
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Authors:
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David S H Bell |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Southern medical journal Volume: 103 ISSN: 1541-8243 ISO Abbreviation: South. Med. J. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-04-20 Revised Date: 2011-10-12 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
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Languages: eng Pagination: 265-7 Citation Subset: AIM; IM |
Affiliation:
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Southside Endocrinology and Division of Diabetes, Endocrinology, and Metabolism, University of Alabama Medical School, Birmingham, AL 35205, USA. dshbell@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Humans Hypoglycemic Agents / adverse effects* Male Metformin / adverse effects* Peripheral Nervous System Diseases / etiology* Vitamin B 12 Deficiency / chemically induced*, complications, diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 657-24-9/Metformin |
| Comments/Corrections | |
Comment In:
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South Med J. 2011 Jul;104(7):541-2; author reply 542
[PMID:
21886057
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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