Document Detail


Metformin-Associated Lactic Acidosis.
MedLine Citation:
PMID:  24326619     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
: Metformin is the most commonly prescribed oral antidiabetic agent. Despite a good safety profile in most patients with diabetes, the risk of metformin-associated lactic acidosis is real if safety guidelines are ignored. Experience with 3 cases of metformin-associated lactic acidosis is reported. Two cases were caused by inappropriate use of metformin in the presence of renal, cardiac and hepatic failure and 1 case followed an intentional overdose. The literature was reviewed on the clinical presentation, prevalence, pathogenesis, prognosis and management of metformin-associated lactic acidosis. This report highlights the importance of proper patient selection, clinical and laboratory monitoring and recommendation on when to stop the drug in ambulatory and hospitalized patients to prevent this unusual but potentially lethal complication.
Authors:
Francisco J Pasquel; Robin Klein; Adaeze Adigweme; Ziad Hinedi; Richard Coralli; Juan L Pimentel; Guillermo E Umpierrez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-10
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Divisions of Endocrinology (FJP, ZH, GEU) and General Medicine (RK, AA), Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; Atlanta Heart Group (RC), Atlanta, GA; and Northwest Nephrology Clinic (JLP), Decatur, Georgia.
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