| Metastatic workup of patients with prostate cancer employing skeletal alkaline phosphatase. | |
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MedLine Citation:
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PMID: 9329584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the efficacy of two tests, prostate-specific antigen (PSA) and skeletal alkaline phosphatase (SAP) as staging markers to discriminate patients with cancer of the prostate (CaP) with bony metastases (M1) from those without bony metastases (Mo). MATERIAL AND METHODS: Forty-seven untreated patients with Mo (n = 26) and M1 (n = 21) CaP were entered in this study. Serum concentrations for SAP and PSA were determined using two immunoassays. RESULTS: None of the Mo patients but 65% of the M1 patients exhibited a SAP value above the reference range (< 19 ng/ml). A corresponding cut-offpoint of 100 ng/ml for PSA showed that 27% of Mo patients and only 65% of the M1 patients exhibited a value > 100 ng/ml. This resulted in a sensitivity and specificity of 65% and 100% for SAP and 65% and 73% for PSA. CONCLUSION: Our findings suggest that SAP could become a useful marker in the evaluation of patients with newly diagnosed CaP as it seems to provide additional information concerning the skeletal status of these patients. |
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Authors:
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J M Wolff; T H Ittel; W Boeckmann; F K Habib; G Jakse |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 17 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 1997 Jul-Aug |
Date Detail:
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Created Date: 1997-10-29 Completed Date: 1997-10-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE |
Other Details:
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Languages: eng Pagination: 2995-7 Citation Subset: IM |
Affiliation:
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Department of Urology, RWTH Aachen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Alkaline Phosphatase / metabolism* Bone Neoplasms / secondary* Bone and Bones / enzymology* Humans Male Middle Aged Prostate-Specific Antigen / blood Prostatic Neoplasms / diagnosis* |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.1/Alkaline Phosphatase; EC 3.4.21.77/Prostate-Specific Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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