Document Detail


Metastatic workup of patients with prostate cancer employing skeletal alkaline phosphatase.
MedLine Citation:
PMID:  9329584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare the efficacy of two tests, prostate-specific antigen (PSA) and skeletal alkaline phosphatase (SAP) as staging markers to discriminate patients with cancer of the prostate (CaP) with bony metastases (M1) from those without bony metastases (Mo). MATERIAL AND METHODS: Forty-seven untreated patients with Mo (n = 26) and M1 (n = 21) CaP were entered in this study. Serum concentrations for SAP and PSA were determined using two immunoassays. RESULTS: None of the Mo patients but 65% of the M1 patients exhibited a SAP value above the reference range (< 19 ng/ml). A corresponding cut-offpoint of 100 ng/ml for PSA showed that 27% of Mo patients and only 65% of the M1 patients exhibited a value > 100 ng/ml. This resulted in a sensitivity and specificity of 65% and 100% for SAP and 65% and 73% for PSA. CONCLUSION: Our findings suggest that SAP could become a useful marker in the evaluation of patients with newly diagnosed CaP as it seems to provide additional information concerning the skeletal status of these patients.
Authors:
J M Wolff; T H Ittel; W Boeckmann; F K Habib; G Jakse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  17     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-10-29     Completed Date:  1997-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2995-7     Citation Subset:  IM    
Affiliation:
Department of Urology, RWTH Aachen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alkaline Phosphatase / metabolism*
Bone Neoplasms / secondary*
Bone and Bones / enzymology*
Humans
Male
Middle Aged
Prostate-Specific Antigen / blood
Prostatic Neoplasms / diagnosis*
Chemical
Reg. No./Substance:
EC 3.1.3.1/Alkaline Phosphatase; EC 3.4.21.77/Prostate-Specific Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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