Document Detail

Metastatic signet ring gastric adenocarcinoma presenting with microangiopathic hemolytic anemia.
MedLine Citation:
PMID:  17986749     Owner:  NLM     Status:  MEDLINE    
Metastatic adenocarcinoma presenting as microangiopathic hemolytic anemia (MAHA) and leukoerythroblastic blood picture is rare. We report three patients who presented with MAHA as the initial symptom of metastatic signet ring cell gastric adenocarcinoma. One patient had past history of gastric ulcer. In all these patients the initial diagnosis was based on peripheral blood smear followed by bone marrow biopsy; upper GI endoscopy showed presence of gastric ulcers with focally scattered neo-plastic signet ring cells on histopathology. All patients died within a week of diagnosis.
Natasha Ali; Nausheen Kamran; Salman Adil; Shahid Pervez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  26     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-11-07     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  185-6     Citation Subset:  IM    
Department of Hematology, The Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.
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MeSH Terms
Anemia, Hemolytic / diagnosis,  etiology*
Biopsy, Needle
Bone Marrow / pathology
Bone Marrow Neoplasms / secondary*
Carcinoma, Signet Ring Cell / secondary*
Middle Aged
Stomach Neoplasms / pathology*

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