Document Detail

Metastatic renal cell carcinoma to the nose and paranasal sinuses.
MedLine Citation:
PMID:  11002329     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Renal cell carcinoma represents 3% of all malignant tumors. Metastatic deposits of renal cell carcinoma to the head and neck region are infrequent. The objective of this work is to analyze the clinical presentation, radiologic features, surgical and radiotherapy treatment, and outcome of metastatic renal cell carcinoma to the nose and sinuses. METHODS: Retrospective review of 6 patients diagnosed with renal cell carcinoma who had nasal metastasis develop and were seen at the Christie Hospital in Manchester over the past 8 years. RESULTS: Six patients with renal cell carcinoma were seen with recurrent epistaxis, nasal obstruction, and unpleasant nasal crusting. Three patients had orbital involvement. Examination under general anaesthesia and biopsy was performed in all 6 cases. Histologic studies confirmed metastases of renal cell carcinoma in all 6 patients. All patients underwent local external beam radiotherapy. The most common dose used was 35 Gy in 8 daily fractions. All patients had symptomatic control of local nasal disease with a minimum follow-up of 2 years in 4 patients. Two patients died within 6 months of the radiotherapy treatment as a result of their primary tumor. CONCLUSIONS: Metastatic renal cell carcinoma to the nose and paranasal sinuses is rare but has unpleasant symptoms. Local symptomatic control with radiotherapy is excellent.
R Simo; A J Sykes; S P Hargreaves; P R Axon; A R Birzgalis; N J Slevin; W T Farrington
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Head & neck     Volume:  22     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-27     Completed Date:  2000-11-30     Revised Date:  2006-10-05    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  722-7     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Inc.
University Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Lewisham, Lewisham High Street, London SE13 6LR, United Kingdom.
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MeSH Terms
Carcinoma, Renal Cell / pathology,  radiotherapy*,  secondary*
Kidney Neoplasms / pathology*
Middle Aged
Nose Neoplasms / pathology,  radiotherapy*,  secondary*
Paranasal Sinus Neoplasms / pathology,  radiotherapy*,  secondary*
Retrospective Studies
Tomography, X-Ray Computed

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