| Metastatic paraganglioma of the spine: Case report and review of the literature. | |
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MedLine Citation:
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PMID: 23398849 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Paragangliomas are relatively rare tumors, accounting for only about 0.3% of all neoplasms. Most paragangliomas are defined as benign in nature, but 10-20% possess metastatic potential. There have been scattered reports of metastatic paraganglioma in the literature, but in rare circumstances, paragangliomas can metastasize to the spinal column causing destruction or compression of the spinal cord, clinically manifesting as pain or neurological deficit. We report a case of metastatic paraganglioma in which a 47-year-old man had spinal metastasis from a primary abdominal paraganglioma and was found to be positive for SDHB mutation, portraying negative implications for prognosis. Long-term follow-up is reported. In addition, we review the literature on the topic of metastatic paraganglioma, management of paragangliomas involving spine, and touch on the importance of the presence of SDHB mutations in these cases. |
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Authors:
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Darryl Lau; Frank La Marca; Sandra Camelo-Piragua; Paul Park |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-8 |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: - ISSN: 1872-6968 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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