Document Detail


Metastatic melanoma presenting as polymorphic ventricular tachycardia.
MedLine Citation:
PMID:  23304048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 41-year-old woman with metastatic melanoma was admitted to the hospital because of syncopal episodes, which had developed after the administration of an experimental chemotherapy agent that targeted Notch signaling, as part of a phase I clinical trial. Cardiac monitoring revealed recurrent episodes of polymorphic ventricular tachycardia correlating with the patient's syncope. Investigations into the cause of the arrhythmia led to the discovery of metastatic lesions within the left ventricular myocardium. In presenting this case of polymorphic ventricular tachycardia as the antemortem clinical manifestation of metastatic melanoma involving the heart, we discuss the importance of recognizing that cardiac metastases can manifest themselves as arrhythmias in patients with malignant melanoma who are undergoing active anticancer treatment.
Authors:
Jyoti Sharma; Jonathan Matthew Brunson; Nada Memon; Aarif Y Khakoo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  39     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-06-11     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  890-3     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas 77054, USA. jyoti.sharma@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Diagnosis, Differential
Electrocardiography*
Female
Heart Neoplasms / complications*,  secondary
Heart Ventricles
Humans
Magnetic Resonance Imaging, Cine
Melanoma / complications*,  secondary
Skin Neoplasms / complications*,  pathology
Tachycardia, Ventricular / diagnosis,  etiology*,  physiopathology
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