Document Detail

Metastatic growth of v-fos-induced osteosarcoma, following in vitro cultivation.
MedLine Citation:
PMID:  1610771     Owner:  NLM     Status:  MEDLINE    
A tumour cell line was established from a non-metastatic osteosarcoma which had developed in the right femur after infection of a newborn mouse with FBR osteosarcoma virus (FBR MSV). After 20 cell culture passages and injection of the cells into newborn syngeneic mice, the animals developed fibrosarcomas on the site of injection. Metastatic lung tumours were detected in 50% of the mice. Metastatic tumour growth was preferentially observed in the walls of large blood vessels and in subpleural zones. Large areas of the metastatic tumours resembled mature connective tissue. This model of in vitro progression from a primary non-metastasizing osteosarcoma to a neoplasm with particular metastatic potency, though with a growth pattern similar to fibromatosis may serve as a useful system to study the different steps of metastatic progression, distinct tropism of invasive cells and fibrous maturation of metastatic tumours.
R Goralczyk; A Luz; V Erfle; J Schmidt
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zentralblatt für Pathologie     Volume:  138     ISSN:  0863-4106     ISO Abbreviation:  Zentralbl. Pathol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-24     Completed Date:  1992-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105594     Medline TA:  Zentralbl Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Institut für Molekulare Virologie, Neuherberg, Deutschland.
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MeSH Terms
Animals, Newborn
Femoral Neoplasms / pathology
Fibrosarcoma / pathology*,  secondary
Genes, fos*
Lung Neoplasms / pathology,  secondary*
Mice, Inbred C3H
Neoplasm Transplantation
Oncogene Proteins v-fos / genetics
Osteosarcoma / pathology*,  secondary
Retroviridae / physiology
Skin Neoplasms / pathology
Tumor Cells, Cultured
Reg. No./Substance:
0/Oncogene Proteins v-fos

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