| Metastatic growth of v-fos-induced osteosarcoma, following in vitro cultivation. | |
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MedLine Citation:
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PMID: 1610771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A tumour cell line was established from a non-metastatic osteosarcoma which had developed in the right femur after infection of a newborn mouse with FBR osteosarcoma virus (FBR MSV). After 20 cell culture passages and injection of the cells into newborn syngeneic mice, the animals developed fibrosarcomas on the site of injection. Metastatic lung tumours were detected in 50% of the mice. Metastatic tumour growth was preferentially observed in the walls of large blood vessels and in subpleural zones. Large areas of the metastatic tumours resembled mature connective tissue. This model of in vitro progression from a primary non-metastasizing osteosarcoma to a neoplasm with particular metastatic potency, though with a growth pattern similar to fibromatosis may serve as a useful system to study the different steps of metastatic progression, distinct tropism of invasive cells and fibrous maturation of metastatic tumours. |
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Authors:
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R Goralczyk; A Luz; V Erfle; J Schmidt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Zentralblatt für Pathologie Volume: 138 ISSN: 0863-4106 ISO Abbreviation: Zentralbl. Pathol. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-07-24 Completed Date: 1992-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105594 Medline TA: Zentralbl Pathol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 97-102 Citation Subset: IM |
Affiliation:
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GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Institut für Molekulare Virologie, Neuherberg, Deutschland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Female Femoral Neoplasms / pathology Fibrosarcoma / pathology*, secondary Genes, fos* Lung Neoplasms / pathology, secondary* Mice Mice, Inbred C3H Neoplasm Transplantation Oncogene Proteins v-fos / genetics Osteosarcoma / pathology*, secondary Retroviridae / physiology Skin Neoplasms / pathology Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Oncogene Proteins v-fos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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