Document Detail

Metastatic cerebral choriocarcinoma coexistent with a viable pregnancy.
MedLine Citation:
PMID:  8626104     Owner:  NLM     Status:  MEDLINE    
Gestational choriocarcinoma associated with a viable pregnancy is extremely rare, and such choriocarcinoma with metastases presenting during the pregnancy is even more exceptional. Metastases from this tumor may present in a variety of ways depending on the site of the metastatic lesion, and can be fatal before choriocarcinoma is even suspected. We describe a 32-year-old primigravida presenting at 31 weeks gestation with a grand mal seizure due to cerebral metastases secondary to gestational choriocarcinoma who was subsequently successfully treated with chemotherapy. To our knowledge this is the first reported case of choriocarcinoma presenting with signs due to cerebral metastases during pregnancy where both the mother and child survived. This paper emphasizes the need to consider metastatic choriocarcinoma in any gravid female who presents with unusual neurological signs because of the life-threatening nature of this potentially curable disease.
A Dana; G J Saldanha; R Doshi; G J Rustin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Gynecologic oncology     Volume:  61     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-06-21     Completed Date:  1996-06-21     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-9     Citation Subset:  IM    
Department of Medical Oncology, Charing Cross Hospital, London, United Kingdom.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Brain Neoplasms / diagnosis,  drug therapy,  secondary*
Choriocarcinoma / diagnosis,  drug therapy,  secondary*
Cyclophosphamide / administration & dosage
Dactinomycin / administration & dosage
Diagnosis, Differential
Etoposide / administration & dosage
Methotrexate / administration & dosage
Pregnancy Complications, Neoplastic*
Vincristine / administration & dosage
Reg. No./Substance:
0/EMA-CO protocol; 33419-42-0/Etoposide; 50-18-0/Cyclophosphamide; 50-76-0/Dactinomycin; 57-22-7/Vincristine; 59-05-2/Methotrexate

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