Document Detail

Metastatic carcinoid disease inducing coronary vasospasm.
MedLine Citation:
PMID:  22412234     Owner:  NLM     Status:  MEDLINE    
Herein, we report a case of progressive coronary vasospasm in a 70-year-old man who had a long-standing history of metastatic gastrointestinal carcinoid tumor. Despite octreotide, nitrate, and calcium channel-blocker therapy, the patient's urinary 5-hydroxy-indole acetic acid level increased, coinciding with an increased frequency of flushing episodes with chest discomfort. In the cardiac catheterization laboratory, we captured an episode that was associated with diffuse right coronary artery spasm, ST-segment elevation, and intense symptoms. We attribute the patient's coronary vasospasm to his metastatic carcinoid disease.
Danny J Eapen; Stephen Clements; Peter Block; Laurence Sperling
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  39     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-11-12     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-8     Citation Subset:  IM    
Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
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MeSH Terms
Alcohol Drinking / adverse effects
Antineoplastic Agents, Hormonal / therapeutic use
Biological Markers / urine
Carcinoid Heart Disease / diagnosis,  etiology*,  therapy
Carcinoid Tumor / complications*,  drug therapy,  secondary
Cardiac Catheterization
Coronary Angiography
Coronary Vasospasm / diagnosis,  etiology*,  therapy
Gastrointestinal Neoplasms / complications*,  drug therapy,  pathology
Hydroxyindoleacetic Acid / urine
Octreotide / therapeutic use
Treatment Outcome
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/Biological Markers; 0/Vasodilator Agents; 54-16-0/Hydroxyindoleacetic Acid; 83150-76-9/Octreotide
Comment In:
Tex Heart Inst J. 2012;39(3):460   [PMID:  22719174 ]

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