Document Detail

Metastatic amelanotic nodular melanoma during pregnancy.
MedLine Citation:
PMID:  18660642     Owner:  NLM     Status:  MEDLINE    
This case report presents a very aggressive course of amelanotic nodular melanoma during pregnancy resulting in death five months after delivery. A 34 year-old Caucasian woman at 19th week of the second pregnancy was diagnosed having amelanotic nodular melanoma (tumor thickness - 2.5 mm) with metastases to the regional right inguinal lymph node. Amelanotic nodular melanoma represents malignant melanocytic tumor of the skin, which clinically mimics a variety of benign and malignant skin conditions and therefore commonly leads to delayed diagnosis. Though primary tumor was excised immediately, other treatment procedures as radical lymphadenectomy and chemotherapy were delayed, and immunotherapy was not given totally. At the 29th week of pregnancy, the woman via naturalem delivered a healthy female child, and the chemotherapy was started. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our reported case. Such patients seems to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.
Daiva Jasaitiene; Skaidra Valiukeviciene; Jurgita Makstiene; Edita Brone Juodzbaliene
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medicina (Kaunas, Lithuania)     Volume:  44     ISSN:  1648-9144     ISO Abbreviation:  Medicina (Kaunas)     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9425208     Medline TA:  Medicina (Kaunas)     Country:  Lithuania    
Other Details:
Languages:  eng     Pagination:  467-71     Citation Subset:  IM    
Department of Skin and Venereal Diseases, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania.
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MeSH Terms
Infant, Newborn
Lymph Node Excision
Lymphatic Metastasis
Melanoma, Amelanotic / diagnosis,  mortality,  pathology,  secondary*,  surgery
Pregnancy Complications, Neoplastic* / diagnosis,  mortality,  pathology,  surgery
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Puerperal Disorders / mortality
Skin / pathology
Skin Neoplasms / diagnosis,  mortality,  pathology,  secondary*,  surgery
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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