| Metastatic alveolar rhabdomyosarcoma in multiple endocrine neoplasia type 2A. | |
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MedLine Citation:
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PMID: 20533522 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, accounts for 3% of childhood malignancies. Multiple Endocrine Neoplasia (MEN) type 2A is an autosomal dominant syndrome associated with near universal development of medullary thyroid carcinoma. We describe a previously unreported association of MEN-2A with metastatic alveolar RMS and review the literature on associated hereditary cancer predisposition syndromes and current therapeutic options. The high penetrance of malignancy in patients with MEN warrants a heightened suspicion for the development of nonendocrine malignancies. The diagnosis of RMS should prompt consideration of screening for familial genetic syndromes in certain patients. |
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Authors:
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Ashley E Jones; Edythe A Albano; Mark A Lovell; Stephen P Hunger |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 55 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1213-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Colorado Denver School of Medicine, The Children's Hospital, Aurora, Colorado, USA. jones.ashley@tchden.org |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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