Document Detail

Metastatic adrenal neuroblastoma in an adult.
MedLine Citation:
PMID:  15933424     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neuroblastoma (NB) is a common malignancy in children, but rarely occurs in adults. Accepted unfavourable prognostic factors include age > 1 year, low histologic grade and advanced stage, MYCN amplification, chromosomal aberrations, elevations of neuron specific enolase and lactate dehydrogenase, and increased catecholamine metabolites in urine or serum. In adults, abdomen/retroperitoneum are the primary sites and in children the adrenal gland. CASE REPORT: A 51- year-old man was admitted to our hospital with hypertension and a large right retroperitoneal mass. Clinically, phaeochromocytoma was suspected. Tumour resection revealed adrenal NB grade III. Chemotherapy according to the paediatric German Neuroblastoma Trial (NB97) was started. Follow-up computed tomography showed regression of the enlarged mediastinal and retroperitoneal lymph nodes. Because of local and systemic progression palliative radiochemotherapy was started. The patient died 9 months after diagnosis. CONCLUSION: To the best of our knowledge this is the oldest NB patient registered so far in Germany. Currently there are no standard treatment guidelines for patients with NB in adulthood. Collection and evaluation of data in adult patients with this tumour are warranted in order to optimise treatment strategies.
Enrico Schalk; Martin Mohren; Michael Koenigsmann; Peter Buhtz; Astrid Franke; Kathleen Jentsch-Ullrich
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-06-02
Journal Detail:
Title:  Onkologie     Volume:  28     ISSN:  0378-584X     ISO Abbreviation:  Onkologie     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-03     Completed Date:  2005-08-23     Revised Date:  2007-12-21    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  353-5     Citation Subset:  IM    
Klinik für Hämatologie/Onkologie, Germany.
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MeSH Terms
Adrenal Gland Neoplasms / pathology*
Lymphatic Metastasis
Middle Aged
Neuroblastoma / pathology*,  secondary*
Rare Diseases / pathology

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