Document Detail

Metastatic epithelioid trophoblastic tumor involving the spine.
MedLine Citation:
PMID:  20802395     Owner:  NLM     Status:  MEDLINE    
STUDY DESIGN: This is a single case-based report.
OBJECTIVE: We report the first case of epithelioid trophoblastic tumor (ETT) presenting as primary metastasis to the spine.
SUMMARY OF BACKGROUND DATA: ETT is an extremely rare form of gestational trophoblastic neoplasm with less than 100 cases reported in the literature. A 36-year-old, postpartum woman presented with severe low back pain and was found to have a contrast-enhancing lesion in lower thoracic spine subsequently confirmed as ETT.
METHODS: The patient data, history, clinical examination findings, laboratory, and histopathology data and imaging studies were retrospectively reviewed and findings reported. A literature search using Pubmed and Cochrane database was conducted.
RESULT: We described the first case of an ETT to present as a primary metastasis to the spine.
CONCLUSION: This first report of metastasis of ETT to the spine adds significant new information to the growing literature of this rare and newly identified tumor. It also alerts the neurosurgeon into considering the diagnosis with appropriate clinical presentation. As more number of cases of nervous system involvement with this tumor are reported, crucial information on prognostic factors and treatment regimens will emerge.
Muhammad Omar Chohan; Tausif Rehman; Lisa A Cerilli; Kelly Devers; Rafael Medina-Flores; Paul Turner
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Spine     Volume:  35     ISSN:  1528-1159     ISO Abbreviation:  Spine     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1072-5     Citation Subset:  IM    
Department of Neurosurgery, University of New Mexico, Albuquerque, NM, USA.
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MeSH Terms
Combined Modality Therapy
Drug Therapy
Fatal Outcome
Low Back Pain / etiology
Magnetic Resonance Imaging
Neurosurgical Procedures
Radiculopathy / etiology
Spinal Neoplasms / diagnosis,  secondary*,  therapy
Thoracic Vertebrae / radiography
Trophoblastic Neoplasms / diagnosis,  secondary*,  therapy
Uterine Neoplasms / diagnosis,  pathology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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