| Metastatic Adrenocortical Carcinoma Presenting Simultaneously with Cushing's and Conn's Syndromes: A Case Report. | |
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MedLine Citation:
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PMID: 21980052 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report the first case of adrenocortical carcinoma secreting cortisol (Cushing's syndrome) and aldosterone (Conn's syndrome) with extensive distant metastasis at the time of diagnosis. A 72-year-old male with exertional dyspnea sought evaluation at our institution. The pattern of tumor spread (lung, pleura, bone and adrenal gland) and respiratory symptoms secondary to the tumor led clinicians to diagnose the primary tumor site as lung cancer and the adrenal mass as a metastatic site. However, endocrinologic studies and a biopsy revealed the primary site to be adrenocortical carcinoma. After histopathologic confirmation, the patient was treated with palliative chemotherapy, including mitotane, cisplatin, etoposide and doxorubicin. The patient died on the 14th day after chemotherapy of rapidly progressive and unexpected pneumonia, which was thought to be an opportunistic infection secondary to Cushing's syndrome. Our case suggests that a thorough endocrinologic investigation is important in patients with an adrenal mass and clinicians should be aware that patients with adrenocortical carcinoma and Cushing's syndrome are susceptible to infections and need to be observed carefully for the possible development of unrecognized opportunistic infections. |
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Authors:
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Seung Hoon Beom; Keun-Wook Lee; Yaewon Yang; Younak Choi; Kyoung-Ho Song; Yu Jung Kim; Jee Hyun Kim; Soo-Mee Bang; Jin-Haeng Chung; Jong Seok Lee |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-6 |
Journal Detail:
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Title: Japanese journal of clinical oncology Volume: - ISSN: 1465-3621 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0313225 Medline TA: Jpn J Clin Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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