Document Detail

Metastasis to the pancreas: characterization by morphology and contrast enhancement features on CT and MRI.
MedLine Citation:
PMID:  18434757     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate the characteristics of metastasis to the pancreas using computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: Twenty-two patients with metastases to the pancreas were examined preoperatively by MRI (7/22) and/or multidetector CT (15/22). Pre- and post-contrast images were acquired and morphology, size, and contrast enhancement of the tumor analyzed. Subsequently, all patients underwent surgery, and the histopathologic findings were compared with the imaging results. RESULTS: In 22 patients, a total of 29 metastases were found on CT and MRI. These metastases originated from renal cell carcinomas (RCC; 22/29), colorectal carcinoma (3/29), and other malignancies (4/29). The metastases differed not in size or location, but in their contrast enhancement characteristics. RCC metastases had either intense homogeneous enhancement (in small lesions) or rim enhancement (in large lesions). Outer regions of colorectal metastases showed no difference from normal pancreatic tissue, whereas the inner area showed hypo-enhancement due to central necrosis. CONCLUSION: Imaging features of metastases from RCC point to their primary origin. While they can be distinguished from primary adenocarcinoma of the pancreas, differentiation from endocrine carcinoma might be difficult. Differentiation of colorectal carcinoma remains to be investigated on larger numbers of cases.
Moritz Palmowski; Nicola Hacke; Stefanie Satzl; Miriam Klauss; Moritz N Wente; Martin Neukamm; Joerg Kleeff; Peter Hallscheidt
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Publication Detail:
Type:  Journal Article     Date:  2008-04-23
Journal Detail:
Title:  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]     Volume:  8     ISSN:  1424-3911     ISO Abbreviation:  Pancreatology     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966936     Medline TA:  Pancreatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany.
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MeSH Terms
Carcinoma, Renal Cell / secondary
Colorectal Neoplasms / pathology
Kidney Neoplasms / pathology
Pancreatic Neoplasms / diagnosis,  pathology,  radiography,  secondary*
Retrospective Studies
Tomography, X-Ray Computed

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