| Metastasis models for human tumors in athymic mice: useful models for drug development. | |
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MedLine Citation:
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PMID: 3480056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although human tumor xenografts have been extensively used for preclinical evaluation of antitumor agents, most of this work has utilized subcutaneous or subrenal capsule assays based on change in tumor size. To obtain experimental models more reflective of the human clinical situations, we have developed several metastatic models that are based on and complement a panel of cell strains used in large-scale in vitro drug screening. One melanoma and four lung tumors produced metastatic lesions in the lung within 60 days following subcutaneous, intraperitoneal, or intrasplenic inoculation of BALB/C athymic nude mice. Several tumors also produced liver lesions, and one lung tumor strain showed metastasis to the brain. The metastatic lesions histologically resembled the tumors that grew at the inoculation site. In vitro and in vivo cell strains were rederived from the metastatic lesions. These systems may provide practical models for experimental drug and immunotherapeutic trials. |
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Authors:
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D L Fine; R Shoemaker; A Gazdar; J G Mayo; O Fodstad; M R Boyd; B J Abbott; P A Donovan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Volume: 1 ISSN: 1043-6995 ISO Abbreviation: Cancer Detect Prev Suppl Publication Date: 1987 |
Date Detail:
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Created Date: 1988-02-24 Completed Date: 1988-02-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8808253 Medline TA: Cancer Detect Prev Suppl Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 291-9 Citation Subset: IM |
Affiliation:
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Program Resources, Inc., National Cancer Institute/Frederick Cancer Research Facility, MD 21701. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use* Cell Line Female Melphalan / therapeutic use Mice Mice, Nude Neoplasm Metastasis / drug therapy*, pathology Neoplasm Transplantation Transplantation, Heterologous |
| Grant Support | |
ID/Acronym/Agency:
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N01-23910//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 148-82-3/Melphalan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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