Document Detail


Metastasis in meningioma.
MedLine Citation:
PMID:  8955436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Meningioma is a neoplastic growth originating from the leptomeninges. Although meningiomas are usually benign, malignant meningiomas with distant metastases occur infrequently. There is little precise information in the literature regarding the frequency of metastases in meningiomas; their incidence has been vaguely reported to be less than 1 per 1,000. Furthermore, most of the previous studies have also included haemangiopericytomas which most recent authorities do not consider meningiomas. In our experience with the management of 396 meningiomas over the past 18 years, 7 meningiomas were classified as malignant by defined histological criteria. After initially presenting as solitary intracranial neoplasms, three of the malignant meningiomas metastasized to extracranial tissues. Collectively, the metastases involved the vertebral bodies, liver, pelvis, long bones, and the spinal cord. This confers an incidence of metastasis of 0.76% when considering all the meningiomas, and an incidence of approximately 43% when considering only malignant meningioma; both percentages are significantly higher than reported previously. This high incidence of metastasis in the malignant meningioma indicates a worse prognosis than formerly assessed and also characterized the malignant meningioma as a primary central nervous system neoplasm with one of the highest rates of metastasis. In addition, when malignant meningioma is classified by following strict criteria, the risk of metastasis in the ensuing clinical course can be predicted with a higher reliability.
Authors:
S A Enam; S Abdulrauf; B Mehta; G M Malik; A Mahmood
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  138     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  1996  
Date Detail:
Created Date:  1997-03-18     Completed Date:  1997-03-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  1172-7; discussion 1177-8     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Bone Neoplasms / pathology,  secondary*,  surgery
Bone and Bones / pathology
Female
Humans
Liver / pathology
Liver Neoplasms / pathology,  secondary*,  surgery
Magnetic Resonance Imaging
Male
Meningeal Neoplasms / pathology,  surgery*
Meninges / pathology
Meningioma / pathology,  secondary*,  surgery
Middle Aged
Neoplasm Invasiveness
Spinal Cord Neoplasms / pathology,  secondary*,  surgery
Spinal Neoplasms / pathology,  secondary*,  surgery
Thoracic Vertebrae / pathology
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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