| Metastases from non-small cell lung cancer: mediastinal staging in the 1990s--meta-analytic comparison of PET and CT. | |
| | |
MedLine Citation:
|
PMID: 10551237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To meta-analytically compare 2-[fluorine 18]fluoro-2-deoxy-D-glucose positron emission tomography (PET) and computed tomography (CT) for the demonstration of mediastinal nodal metastases in patients with non-small cell lung cancer. MATERIALS AND METHODS: English-language reports on the diagnostic performance of PET (14 studies, 514 patients) and/or CT (29 studies, 2,226 patients) for demonstration of mediastinal nodal metastases from NSCLC were selected by using the MEDLINE database. In eligible studies, an objective diagnostic standard was used, data were presented to allow recalculation of contingency tables, and established diagnostic criteria were used for abnormal test results. Summary receiver operating characteristic (ROC) curves were calculated. RESULTS: Pooled point estimates of diagnostic performance and summary ROC curves indicated that PET was significantly more accurate than CT for demonstration of nodal metastases (P < .001). Mean sensitivity and specificity (+/- 95% CI) were 0.79 +/- 0.03 and 0.91 +/- 0.02, respectively, for PET and 0.60 +/- 0.02 and 0.77 +/- 0.02, respectively, for CT. The log odds ratios were 1.79 (95% CI: 1.49, 2.09) for CT and 3.77 (95% CI: 2.77, 4.77) for PET (P < .001). Subgroup analyses did not alter findings. CONCLUSION: PET is superior to CT for mediastinal staging of non-small cell lung cancer, independent of performance index or clinical context of PET imaging. |
| | |
Authors:
|
B A Dwamena; S S Sonnad; J O Angobaldo; R L Wahl |
Related Documents
:
|
12752087 - Accuracy of whole-body 18f-fdp-pet for restaging malignant lymphoma. 7492457 - Imaging and staging of small-cell lung cancer: is there a future role for octreotide sc... 20679447 - Viscoelasticity-based staging of hepatic fibrosis with multifrequency mr elastography. 20926977 - Utility of fluorodeoxyglucose-positron emission tomography in the identification of new... 7254517 - Meningioma in the tela choroidea of the third ventricle: ct and angiographic correlations. 11044947 - Mri-visible pericochlear lesions in osteogenesis imperfecta type i. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Meta-Analysis |
Journal Detail:
|
Title: Radiology Volume: 213 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 1999-12-07 Completed Date: 1999-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 530-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carcinoma, Non-Small-Cell Lung
/
radiography*,
radionuclide imaging*,
secondary Humans Lung Neoplasms / pathology, radiography*, radionuclide imaging* Lymphatic Metastasis Mediastinum Neoplasm Staging ROC Curve Sensitivity and Specificity Tomography, Emission-Computed* Tomography, X-Ray Computed* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sentinel lymph node mapping for breast cancer: analysis in a diverse patient group.
Next Document: Cystic fibrosis: CT assessment of lung involvement in children and adults.