Document Detail

Metaplastic thymoma: report of an unusual thymic epithelial neoplasm arising in the wall of a thymic cyst.
MedLine Citation:
PMID:  18397900     Owner:  NLM     Status:  MEDLINE    
In this report, a case of metaplastic thymoma arising in a thymic cyst wall is discussed. The patient was a 61-year-old male whose chief complaint was sweating and chest pain. Imaging study revealed a mediastinal mass with right hemithoracic extension. He underwent surgical resection of the mass and remnants of the thymus. Histologic studies showed a primary thymic neoplasm with a biphasic histologic pattern composed of 2 distinct epithelial and stromal components arising in a thymic cyst wall. Immunohistochemically, the epithelial component was cytokeratin positive and focally reactive for EMA. Marked expression of EMA and vimentin was seen in spindle cells. Metaplastic thymoma is an extremely rare variant of primary thymic epithelial neoplasms with only a few cases reported in the literature.
Mihan Poorabdollah; Ehsan Mehdizadeh; Foruzan Mohammadi; Shahram Sabeti
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-04-07
Journal Detail:
Title:  International journal of surgical pathology     Volume:  17     ISSN:  1066-8969     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  IM    
Department of Surgical Pathology, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Science and Health Services, Tehran, Iran.
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MeSH Terms
Mediastinal Cyst / complications*
Middle Aged
Mucin-1 / metabolism
Neoplasms, Glandular and Epithelial / diagnosis*,  metabolism,  pathology
Thymoma / diagnosis*,  metabolism,  pathology
Thymus Neoplasms / diagnosis*,  metabolism,  pathology
Vimentin / metabolism
Reg. No./Substance:
0/Mucin-1; 0/Vimentin

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