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Metaplastic thymoma of the mediastinum: a clinicopathologic, immunohistochemical, and genetic analysis.
MedLine Citation:
PMID:  22261452     Owner:  NLM     Status:  In-Data-Review    
Metaplastic thymoma is a rare primary thymic epithelial tumor, and its biologic behavior is uncertain. We report 7 cases of metaplastic thymoma. The spindle components of the tumor seemed to be undergoing epithelial-mesenchymal transition, which is characterized by the loss of E-cadherin expression. Epstein-Barr virus seemed not to have an etiologic role in metaplastic thymoma. No gross genetic alterations were found by using comparative genomic hybridization. The patients were alive and well in follow-up ranging from 11 to 172 months (mean, 81.7 months). The findings suggest that metaplastic thymoma has a benign clinical course. Unless the histomorphologic findings show malignant features, surgical excision alone is recommended.
Biao Liu; Qiu Rao; Yun Zhu; Bo Yu; Hai-Yan Zhu; Xiao-Jun Zhou
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  137     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-9     Citation Subset:  AIM; IM    
Dept of Pathology, Clinical School of Medical College of Nanjing University/Nanjing Jinling Hospital, Nanjing, Jiangsu 210002, China.
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