| Metaplastic Variant of Invasive Micropapillary Breast Carcinoma: A Unique Triple Negative Phenotype. | |
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MedLine Citation:
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PMID: 22334616 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Invasive micropapillary carcinomas (IMC) and metaplastic breast carcinoma (MBC) have different clinicopathologic features. This study reports an unusual case of multifocal grade III IMC associated with MBC component in a 35-year-old woman. MBC was vimentin positive, pancytokeratin negative, and showed focal p63 positivity. Immunostains for estrogen and progesterone receptor, and fluorescence in situ hybridization for Her2/neu amplification were negative. All the left axillary lymph nodes dissected were positive for metastatic carcinoma with ductal and IMC patterns, but without metaplastic component. Postmastectomy computed tomography and magnetic resonance imaging scans showed metastases to lungs, liver, brain, and vertebrae. The biologic behavior of tumor was in accordance with histology, so that the nodal and distant metastases were testament to the underlying inherently aggressive IMC, whereas large tumor size and triple negativity reflected the features of MBC. To the best of the authors' knowledge, this is the first report of a metaplastic variant of invasive micropapillary breast carcinoma with triple negative phenotype. |
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Authors:
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Gitika Aggarwal; Michelle Dian Reid; Suash Sharma |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-13 |
Journal Detail:
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Title: International journal of surgical pathology Volume: - ISSN: 1940-2465 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9314927 Medline TA: Int J Surg Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Georgia Health Sciences University, Augusta, GA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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