Document Detail


Metallothionein concentration in the mussel Mytilus galloprovincialis as a biomarker of response to metal contamination: validation in the field.
MedLine Citation:
PMID:  12581483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mussels were translocated from a shell-fish breeding area (Sète, on the French Mediterranean coast) to sites exposed to trace element inputs in April 2000. They were recovered 3 months later. Whole soft tissues from all of the sites (n = 97) were analysed for arsenic, cadmium, chromium, copper, mercury, nickel, lead and zinc. Metallothioneins (MTs) were also measured in the digestive gland and in the remaining tissues (allowing calculation of whole soft tissue concentrations) at 22 of the 97 sites. MT concentrations in the digestive gland and the whole soft tissues were strongly correlated. The condition index varied with food availability at different sites. This did not influenced MT concentrations in the whole soft tissues, whereas the condition index was negatively correlated to trace element concentrations. A model is proposed to minimize this influence of condition. Metal concentrations adjusted using this model showed significant correlations with MT levels for those metals (cadmium, copper, nickel and zinc) that are known to bind to this protein, with the exception of mercury. Even in moderately contaminated sites, measurement of the MT level in the soft tissues of mussels was generally able to discriminate between different levels of contamination, allowing the use of a simplified procedure compared with dissection of the digestive gland. It is recommended to avoid translocation and sampling during the reproductive period, which is well documented for commercial species such as Mytilus sp.
Authors:
Yohan Mourgaud; Eric Martinez; Alain Geffard; Bruno Andral; Jean-Yves Stanisiere; Jean-Claude Amiard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  7     ISSN:  1354-750X     ISO Abbreviation:  Biomarkers     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  479-90     Citation Subset:  IM    
Affiliation:
Service d'Ecotoxicologie, CNRS GDR 1117, ISOMer, SMAB, 2 Rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / analysis
Bivalvia / metabolism*
Environmental Monitoring / methods,  standards
Metallothionein / analysis*
Metals, Heavy / analysis*,  pharmacokinetics
Tissue Distribution
Water Pollutants, Chemical / analysis*,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Metals, Heavy; 0/Water Pollutants, Chemical; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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