| Metallothionein and brain inflammation. | |
| | |
MedLine Citation:
|
PMID: 21678079 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Since the seminal discoveries of Bert Vallee regarding zinc and metallothioneins (MTs) more than 50 years ago, thousands of studies have been published concerning this fascinating story. One of the most active areas of research is the involvement of these proteins in the inflammatory response in general, and in neuroinflammation in particular. We describe the general aspects of the inflammatory response, highlighting the essential role of the major cytokine interleukin-6, and review briefly the expression and function of MTs in the central nervous system in the context of neuroinflammation. Particular attention is paid to the Tg2576 Alzheimer disease mouse model and the preliminary results obtained in mice into which human Zn(7)MT-2A was injected, which suggest a reversal of the behavioral deficits while enhancing amyloid plaque load and gliosis. |
| | |
Authors:
|
Yasmina Manso; Paul A Adlard; Javier Carrasco; Milan Vašák; Juan Hidalgo |
Related Documents
:
|
21869599 - Coordinated epigenetic regulation of autophagy and apoptosis. 20133049 - Proteasome inhibition: a new therapeutic strategy to cancer treatment. 9681509 - Transforming growth factor-beta1 induces nuclear to cytoplasmic distribution of androge... 19279129 - Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondria... 20729919 - Cip2a mediates effects of bortezomib on phospho-akt and apoptosis in hepatocellular car... 19171189 - Withdrawn: fem1b interacts with ankrd37 in mouse testis and induces its degradation by ... 21616659 - Curcumin improves mmc-based chemotherapy by simultaneously sensitising cancer cells to ... 11991629 - Butyrate strongly inhibits in vitro stimulated release of cytokines in blood. 9628459 - Diminished monocytic hla-dr expression and ex vivo cytokine secretion capacity in patie... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-16 |
Journal Detail:
|
Title: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry Volume: - ISSN: 1432-1327 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9616326 Medline TA: J Biol Inorg Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Animal Physiology Unit, Department of Cellular Biology, Physiology and Immunology, Faculty of Biosciences, Institute of Neurosciences, Universitat Autonoma Barcelona, Bellaterra, 08193, Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anisotropies of linear and curvilinear completions at the blind spot.
Next Document: Competitive binding of Fe(3+), Cr (3+), and Ni (2+) to transferrin.