Document Detail

Metalloproteinases and Advanced Glycation End Products: Coupled Navigation in Atherosclerotic Plaque Pathophysiology?
MedLine Citation:
PMID:  23073918     Owner:  NLM     Status:  Publisher    
Matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and inflammatory cytokines, such as interleukin-1 (IL-1), are considered markers of evolution and/or instability of atherosclerotic plaques. Accumulation of Advanced Glycation Endproducts (AGE) is a well known phenomenon in diabetes and has also been considered in the pathogenesis of atherosclerosis. Aim of the present study was to analyse the levels of pentosidine, a fluorescent AGE, and to evaluate the expression of MMP-2, TIMP-3, and IL-1 in an ex vivo model of human advanced atherosclerotic plaques. We intended to test the possible correlation between pentosidine and markers of ECM remodelling and inflammation in the atherosclerotic process, and to investigate if classic risk factors, such as diabetes and hypertension, influenced these biochemical parameters. We found that diabetic plaques showed higher level of pentosidine, as expected, but much lower, or even undetectable, expression levels of MMP-2 and TIMP-3; IL-1 expression was not different between diabetic and non diabetic plaques. Hypertension did not influence any of these parameters. Although the statistical correlations between the expression of the considered genes and pentosidine did not reach significance, slight negative trends were noted between TIMP-3 and IL-1 expression vs. pentosidine content. We suggest that in mature diabetic plaques AGE accumulation can exert stabilizing effects on matrix proteins, while scanty cell presence leads to poor capacity of reactive responses, such as remodelling and inflammation.
A L Furfaro; R Sanguineti; D Storace; F Monacelli; A Puzzo; M A Pronzato; P Odetti; N Traverso
Related Documents :
24705608 - Left ventricular hypertrophy and insulin resistance in adults from an urban community i...
23519188 - Diabetic muscle infarction: two cases: one with recurrent and bilateral lesions and one...
23853618 - Temporal changes in plasma concentration of leptin, igf-1, insulin and metabolites unde...
24632248 - Intestinal absorption of insulin nanoparticles: contribution of m cells.
6380308 - Defective glucose counterregulation limits intensive therapy of diabetes mellitus.
6624908 - Absence of hepatic extraction of pancreatic polypeptide in conscious dogs.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-16
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  -     ISSN:  1439-3646     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.
DIMES, Section of General Pathology, University of Genova, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessment of Small Fiber Neuropathy through a Quick, Simple and Non Invasive Method in a German Dia...
Next Document:  Relationship between Plasma Antioxidants and Thyroid Hormones in Chronic Obstructive Pulmonary Disea...