| Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: a study in the atherosclerotic Yucatan micropig. | |
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MedLine Citation:
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PMID: 10869270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Arterial remodeling after balloon angioplasty has been recognized as a major determinant of restenosis. Perturbation of collagen metabolism might be important. After balloon injury, matrix metalloproteinase (MMP) expression is upregulated. We investigated the effect of Batimastat, a nonspecific MMP inhibitor, on late lumen loss, arterial remodeling, and neointima formation after balloon dilation. METHODS AND RESULTS: In atherosclerotic iliac arteries of 12 Yucatan micropigs, balloon dilation was performed, with intravascular ultrasound and quantitative angiography used before and after balloon dilation and at 42-day follow-up. The animals were randomly divided into 2 groups, the Batimastat group (n=6) and the vehicle group (n=6). All animals were intraperitoneally injected with either Batimastat or a vehicle immediately after balloon dilation and at 2 weeks and 4 weeks after balloon dilation. Angiographic and echographic late lumen loss in the Batimastat group versus the vehicle group was 0.3+/-0.1 versus 0.8+/-0.1 mm (P=0.01) and 2.2+/-0.5 versus 4.9+/-0.7 mm(2) (P=0.004), respectively. Late media-bounded area loss was used as a measure of remodeling after balloon dilation and was 0.9+/-0.6 mm(2) in the Batimastat group compared with 3.8+/-0.8 mm(2) in the vehicle group (P=0.003, mixed model analysis P=0.01). Neointima formation was 1.3+/-0.3 mm(2) in the Batimastat group and 1.0+/-0.2 mm(2) in the vehicle group (P=0. 542). CONCLUSIONS: Metalloproteinase inhibition by Batimastat significantly reduced late lumen loss after balloon angioplasty by inhibition of constrictive arterial remodeling, whereas neointima formation was not inhibited by MMP inhibition. |
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Authors:
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B J de Smet; D de Kleijn; R Hanemaaijer; J H Verheijen; L Robertus; Y J van Der Helm; C Borst; M J Post |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 101 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-19 Completed Date: 2000-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2962-7 Citation Subset: AIM; IM |
Affiliation:
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Heart Lung Institute, Utrecht University Hospital, and the Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Angioplasty, Balloon / adverse effects* Animals Arteriosclerosis / diagnosis, etiology*, metabolism, therapy* Iliac Artery / pathology, physiopathology*, ultrasonography Immunohistochemistry Macrophages / pathology Metalloendopeptidases / antagonists & inhibitors*, metabolism Phenylalanine / analogs & derivatives*, blood, therapeutic use Postoperative Period Protease Inhibitors / therapeutic use* Swine Swine, Miniature Thiophenes / blood, therapeutic use* Tunica Intima / pathology, radiography, ultrasonography Ultrasonography, Interventional |
| Chemical | |
Reg. No./Substance:
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0/Protease Inhibitors; 0/Thiophenes; 130370-60-4/batimastat; 63-91-2/Phenylalanine; EC 3.4.24.-/Metalloendopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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