Document Detail

Metalloprotease (ADAM12-S) as a predictor of preeclampsia: correlation with severity, maternal complications, fetal outcome, and Doppler parameters.
MedLine Citation:
PMID:  22676623     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the first trimesteric serum level of ADAM12-S in women who developed mild and severe preeclampsia and in healthy gravidas and to correlate these changes with the severity of the disease, maternal complications, fetal outcome, and Doppler cerebroplacental ratio (CPR).
DESIGN: Comparative prospective observational study.
SETTING: University hospital.
METHODS: Serum samples were obtained from 414 women in their first trimester, of which 259 women completed their pregnancy without complications and 155 women developed preeclampsia later in their pregnancies. All were subjected to history taking, examination, laboratory investigations, obstetric ultrasound, and Doppler CPR.
RESULTS: ADAM12-S was significantly decreased in patients with severe and in mild preeclampsia compared with the controls. Moreover, there was strong negative correlation with disseminated intravascular coagulopathy (DIC) and HELLP syndrome, cesarean delivery, postpartum hemorrhage, and neonatal intensive care unit admission. ADAM12-S had medium negative correlation with systolic blood pressure and diastolic blood pressure, accidental hemorrhage, cesarean hysterectomy, prematurity, and low birth weight. In addition, it had a weak negative correlation with intracranial hemorrhage, residual hypertension, and intrauterine fetal death. ADAM12-S had strong positive correlation with CPR. There were no correlation with eclampsia, intrauterine growth retardation, acute pulmonary edema, and acute renal failure.
CONCLUSION: ADAM12-S is significantly decreased in severe and mild preeclampsia and is correlated with CPR, severity of preeclampsia, maternal complications, and fetal outcome. It is recommended to measure ADAM12-S in the first trimester to predict maternal complications and fetal outcome in pregnancies complicated by preeclampsia.
Walid El-Sherbiny; Ahmed Nasr; Aml Soliman
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Publication Detail:
Type:  Comparative Study; Journal Article; Review     Date:  2012-06-07
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  31     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-03     Completed Date:  2013-02-19     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  442-50     Citation Subset:  IM    
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MeSH Terms
ADAM Proteins / blood*
Biological Markers / blood
Case-Control Studies
Egypt / epidemiology
Infant, Newborn
Infant, Newborn, Diseases / epidemiology
Membrane Proteins / blood*
Pre-Eclampsia / blood*,  epidemiology
Pregnancy Trimester, First
Reg. No./Substance:
0/Biological Markers; 0/Membrane Proteins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins

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