Document Detail


Metalloenzyme-like catalyzed isomerizations of sugars by Lewis acid zeolites.
MedLine Citation:
PMID:  22665778     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Isomerization of sugars is used in a variety of industrially relevant processes and in glycolysis. Here, we show that hydrophobic zeolite beta with framework tin or titanium Lewis acid centers isomerizes sugars, e.g., glucose, via reaction pathways that are analogous to those of metalloenzymes. Specifically, experimental and theoretical investigations reveal that glucose partitions into the zeolite in the pyranose form, ring opens to the acyclic form in the presence of the Lewis acid center, isomerizes into the acyclic form of fructose, and finally ring closes to yield the furanose product. The zeolite catalysts provide processing advantages over metalloenzymes such as an ability to work at higher temperatures and in acidic conditions that allow for the isomerization reaction to be coupled with other important conversions.
Authors:
Ricardo Bermejo-Deval; Rajeev S Assary; Eranda Nikolla; Manuel Moliner; Yuriy Román-Leshkov; Son-Jong Hwang; Arna Palsdottir; Dorothy Silverman; Raul F Lobo; Larry A Curtiss; Mark E Davis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-4
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  -     ISSN:  1091-6490     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.
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