| Metallobiology of host-pathogen interactions: an intoxicating new insight. | |
| | |
MedLine Citation:
|
PMID: 22305804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Iron, zinc and copper, among others, are transition metals with multiple biological roles that make them essential elements for life. Beyond the strict requirement of transition metals by the vertebrate immune system for its proper functioning, novel mechanisms involving direct metal intoxication of microorganisms are starting to be unveiled as important components of the immune system, in particular against Mycobacterium tuberculosis. In parallel, metal detoxification systems in bacteria have been recently characterized as crucial microbial virulence determinants. Here, we will focus on these exciting advancements implicating copper- and zinc-mediated microbial poisoning as a novel innate immune mechanism against microbial pathogens, shedding light on an emerging field in the metallobiology of host-pathogen interactions. |
| | |
Authors:
|
Hélène Botella; Gustavo Stadthagen; Geanncarlo Lugo-Villarino; Chantal de Chastellier; Olivier Neyrolles |
Related Documents
:
|
1550404 - Production and modulation of interleukin 6 synthesis by synoviocytes derived from patie... 9628464 - Calcitonin gene-related peptide potentiates lps-induced il-6 release from mouse periton... 21637354 - Suppression by ghrelin of porphyromonas gingivalis-induced constitutive nitric oxide sy... 8623544 - Hsv-1-mediated modulation of cytokine gene expression in a permissive cell line: select... 22332114 - Testicular connexin 43, a precocious molecular target for the effect of environmental t... 7981604 - To be or not to be: mutually antagonistic death signals regulate thymocyte apoptosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
|
Title: Trends in microbiology Volume: - ISSN: 1878-4380 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9310916 Medline TA: Trends Microbiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Centre National de la Recherche Scientifique (CNRS), Institut de Pharmacologie et de Biologie Structurale (IPBS), BP 64182, F-31077 Toulouse, France; Université de Toulouse, Université Paul Sabatier (UPS), IPBS, F-31077 Toulouse, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab...
Next Document: Coping with health care expenses among poor households: Evidence from a rural commune in Vietnam.