Document Detail

Metallo-beta-lactamase inhibitory activity of phthalic acid derivatives.
MedLine Citation:
PMID:  19632114     Owner:  NLM     Status:  MEDLINE    
4-Butyl-3-methylphthalic acid was recognized as a metallo-beta-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.
Yukiko Hiraiwa; Akihiro Morinaka; Takayoshi Fukushima; Toshiaki Kudo
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Publication Detail:
Type:  Journal Article     Date:  2009-07-09
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  19     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  5162-5     Citation Subset:  IM    
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, Japan.
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MeSH Terms
Anti-Bacterial Agents / chemical synthesis,  chemistry*,  pharmacology
Microbial Sensitivity Tests
Phthalic Acids / chemical synthesis,  chemistry*,  pharmacology
Pseudomonas aeruginosa / drug effects
Structure-Activity Relationship
Thienamycins / pharmacology
beta-Lactamases / antagonists & inhibitors*,  metabolism
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Phthalic Acids; 0/Thienamycins; 120410-24-4/biapenem; EC

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