Document Detail


Metal-organic frameworks as potential drug delivery systems.
MedLine Citation:
PMID:  23140545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Metal-organic frameworks (MOFs) are a unique class of hybrid porous solids based on metals and organic linkers. Compared to traditional porous materials, they possess predominance of large surface areas, tunable pore size and shape, adjustable composition and functionalized pore surface, which enable them unique advantages and promises for applications in adsorption and release of therapeutic agents.
AREAS COVERED: This review addresses MOFs as a new avenue for drug delivery and exhibits their ability to efficiently deliver various kinds of therapeutic agents. It also details the requirements that MOFs need to satisfy for biomedical application, such as toxicological compatibility, stability, particle size, and surface modification. In addition, several approaches used to enhance encapsulation efficiency are summarized and parameters influencing delivery efficiency are also discussed.
EXPERT OPINION: Benefiting from the unique advantages of MOFs materials, efficient delivery of various kinds of drugs has been achieved in some MOF materials. However, it is only the outset of MOFs in drug delivery system, and numerous work need to be done before clinical applications, for example, studying their in vivo toxicity, exploring degradation mechanisms so as to establish real stability of MOFs in body's liquid, providing appropriated surface modification avenue for MOFs, and researching in vivo efficiency and pharmacokinetics of drug-loaded MOFs.
Authors:
Chun-Yi Sun; Chao Qin; Xin-Long Wang; Zhong-Min Su
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-10
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  10     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-07-03     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-101     Citation Subset:  IM    
Affiliation:
Northeast Normal University, Institute of Functional Materials Chemistry, Department of Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Changchun, Jilin, 130024, China. zmsu@nenu.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Animals
Biocompatible Materials
Drug Delivery Systems*
Humans
Organometallic Compounds / chemistry*
Particle Size
Porosity
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Organometallic Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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