| Metal ion and vitamin adsorption profiles of phosphate binder ion-exchange resins. | |
| | |
MedLine Citation:
|
PMID: 20040349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To determine the metal ion and vitamin in vitro adsorption profile of sevelamer hydrochloride (sevelamer-HCl) and colestilan(INN)/colestimide(JAN), a novel ion-exchange resin being developed as a phosphate binder for end-stage renal disease (ESRD) patients undergoing hemodialysis, adsorption of metal ions (iron, cobalt, copper and zinc) and vitamins (B6, B12, C, K and folic acid) essential for hematopoiesis/blood coagulation was assessed. METHODS: Mixtures of each resin (colestilan or sevelamer-HCl, 4 mg/ml) and metal ions (Fe(III), Fe(II), Co(II), Cu(II), and Zn(II), 1 microg/ml) were adjusted to pH 1.2 or 6.8 and incubated at 37 degrees C for 1 hour. Metal ions in the recovered filtrate were detected by inductively coupled plasma optical emission spectrometry. In addition, the mixtures of each resin (4 mg/ml) and vitamins (B6, B12, C, K and folic acid, 0.5 - 250 microg/ml) were adjusted to pH 6.8 and incubated at 37 degrees C for 0.5 hour. The vitamin concentrations in the recovered filtrate were quantified by HPLC. RESULTS: Colestilan did not adsorb any metals tested at either pH level, whereas sevelamer-HCl adsorbed copper(II) and zinc(II) ion at pH 6.8 with adsorption ratios of 99% and 38%, respectively. Both resins showed almost complete adsorption of vitamin C, vitamin K, and folic acid, but weak adsorption of vitamin B6, and no adsorption of vitamin B12. CONCLUSIONS: The differing adsorption profiles for metal ions and vitamins between sevelamer-HCl and colestilan may be of importance for the individualized management of anemia and malnutrition in chronic hemodialysis patients receiving phosphate binding ion-exchange resins for the control of hyperphosphatemia. |
| | |
Authors:
|
K Takagi; K Masuda; M Yamazaki; C Kiyohara; S Itoh; M Wasaki; H Inoue |
Related Documents
:
|
21155539 - Synthesis, electronic structure, dna and protein binding, dna cleavage, and anticancer ... 21301099 - Crystallization and preliminary x-ray diffraction analysis of the wild-type haloalkane ... 21240439 - Pseudo jahn-teller origin of cis-trans and other conformational changes. the role of do... 21202249 - Catena-poly[[cyclo-hexyl-diphenyl-tin(iv)]-μ-hydroxido-κo:o]. 21523089 - N-(4-chloro-butano-yl)-n'-phenyl-thio-urea. 21309559 - Nontrivial redox behavior of nanosized cobalt: new insights from ambient pressure x-ray... 19471879 - A new triterpenoid from brucea javanica. 11237449 - Metallomicellar catalysis cleavage of p-nitrophenyl picolinate catalyzed by binuclear m... 8631869 - The conformational properties of the highly selective cannabinoid receptor ligand cp-55... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical nephrology Volume: 73 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-30 Completed Date: 2010-03-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
|
Languages: eng Pagination: 30-5 Citation Subset: IM |
Affiliation:
|
Research Division, Mitsubishi Tanabe Pharma Corporation, Chiba, Japan. Takagi.Kan@me.mt-pharma.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adsorption Bile Acids and Salts / chemistry Cations / chemistry* Ion Exchange Resins / chemistry* Metals, Heavy / chemistry* Polyamines / chemistry Vitamins / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 0/Cations; 0/Ion Exchange Resins; 0/Metals, Heavy; 0/Polyamines; 0/Vitamins; 0/cholebine; 182683-00-7/sevelamer |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: B-type natriuretic peptide and severe heart failure at baseline predict overall mortality in inciden...
Next Document: Emotional symptoms, quality of life and cytokine profile in hemodialysis patients.