Document Detail


Metal ion and vitamin adsorption profiles of phosphate binder ion-exchange resins.
MedLine Citation:
PMID:  20040349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To determine the metal ion and vitamin in vitro adsorption profile of sevelamer hydrochloride (sevelamer-HCl) and colestilan(INN)/colestimide(JAN), a novel ion-exchange resin being developed as a phosphate binder for end-stage renal disease (ESRD) patients undergoing hemodialysis, adsorption of metal ions (iron, cobalt, copper and zinc) and vitamins (B6, B12, C, K and folic acid) essential for hematopoiesis/blood coagulation was assessed. METHODS: Mixtures of each resin (colestilan or sevelamer-HCl, 4 mg/ml) and metal ions (Fe(III), Fe(II), Co(II), Cu(II), and Zn(II), 1 microg/ml) were adjusted to pH 1.2 or 6.8 and incubated at 37 degrees C for 1 hour. Metal ions in the recovered filtrate were detected by inductively coupled plasma optical emission spectrometry. In addition, the mixtures of each resin (4 mg/ml) and vitamins (B6, B12, C, K and folic acid, 0.5 - 250 microg/ml) were adjusted to pH 6.8 and incubated at 37 degrees C for 0.5 hour. The vitamin concentrations in the recovered filtrate were quantified by HPLC. RESULTS: Colestilan did not adsorb any metals tested at either pH level, whereas sevelamer-HCl adsorbed copper(II) and zinc(II) ion at pH 6.8 with adsorption ratios of 99% and 38%, respectively. Both resins showed almost complete adsorption of vitamin C, vitamin K, and folic acid, but weak adsorption of vitamin B6, and no adsorption of vitamin B12. CONCLUSIONS: The differing adsorption profiles for metal ions and vitamins between sevelamer-HCl and colestilan may be of importance for the individualized management of anemia and malnutrition in chronic hemodialysis patients receiving phosphate binding ion-exchange resins for the control of hyperphosphatemia.
Authors:
K Takagi; K Masuda; M Yamazaki; C Kiyohara; S Itoh; M Wasaki; H Inoue
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  73     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-30     Completed Date:  2010-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Affiliation:
Research Division, Mitsubishi Tanabe Pharma Corporation, Chiba, Japan. Takagi.Kan@me.mt-pharma.co.jp
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Bile Acids and Salts / chemistry
Cations / chemistry*
Ion Exchange Resins / chemistry*
Metals, Heavy / chemistry*
Polyamines / chemistry
Vitamins / chemistry*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cations; 0/Ion Exchange Resins; 0/Metals, Heavy; 0/Polyamines; 0/Vitamins; 0/cholebine; 182683-00-7/sevelamer

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