Document Detail


Metal complex catalysis in living biological systems.
MedLine Citation:
PMID:  23250079     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This feature article discusses synthetic metal complexes that are capable of catalyzing chemical transformations in living organisms. Photodynamic therapy exemplifies what is probably the most established artificial catalytic process exploited in medicine, namely the photosensitized catalytic generation of cell-damaging singlet oxygen. Different redox catalysts have been designed over the last two decades to target a variety of redox alterations in cancer and other diseases. For example, pentaazamacrocyclic manganese(ii) complexes catalyze the dismutation of superoxide to O(2) and H(2)O(2)in vivo and thus reduce oxidative stress in analogy to the native enzyme superoxide dismutase. Recently, piano-stool ruthenium and iridium complexes were reported to influence cellular redox homeostasis indirectly by catalytic glutathione oxidation and catalytic transfer hydrogenation using the coenzyme NADH, respectively. Over the last few years, significant progress has been made towards the application of non-biological reactions in living systems, ranging from the organoruthenium-catalyzed cleavage of allylcarbamates and a gold-catalyzed intramolecular hydroarylation to palladium-catalyzed Suzuki-Miyaura and Sonogashira cross-couplings within the cytoplasm or on the surface of living cells. The design of bioorthogonal catalyst/substrate pairs, which can passively diffuse into cells, combines the advantages of small molecules with catalysis and promises to provide exciting new tools for future chemical biology studies.
Authors:
Pijus K Sasmal; Craig N Streu; Eric Meggers
Related Documents :
23590179 - Concentration dependent supramolecular engineering of h-bonded nanostructures at surfac...
23952569 - Cucl2 for the isolation of a broad array of endohedral fullerenes containing metallic, ...
23320679 - Structural studies of aromatic carboxylic acids via computational chemistry and microwa...
23864839 - Novel organotin(iv) schiff base complexes with histidine derivatives: synthesis, charac...
23202239 - Thiol reactive probes and chemosensors.
23172609 - Eu(fod)(3) binding on the (1) h-nmr spectra of bis(2'-ethylbenzoate)ethylene glycol pod...
17687459 - Kinetic parameters for gas-phase reactions: experimental and theoretical challenges.
22418109 - Photoinduced helical inversion in cholesteric liquid crystal cells with homeotropic anc...
14653689 - Efficient route to 1,3-di-n-imidazolylbenzene. a comparison of monodentate vs bidentate...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-19
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35043 Marburg, Germany. meggers@chemie.uni-marburg.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A new tool to inform intra-operative decision making in skin cancer treatment: the non-invasive asse...
Next Document:  Walking training affects dehydroepiandrosterone sulfate and inflammation independent of changes in s...