Document Detail


Metal impurities in food and drugs.
MedLine Citation:
PMID:  20217462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The major metals of potential health concern found in food, drugs (medicines), and dietary supplements are lead, cadmium, mercury, and arsenic. Other metals, such as chromium, copper, manganese, molybdenum, vanadium, nickel, osmium, rhodium, ruthenium, iridium, palladium, and platinum, may be used or introduced during manufacturing and may be controlled in the final article as impurities. Screening for metals in medicines and dietary supplements rarely indicates the presence of toxic metal impurities at levels of concern. The setting of heavy metal limits is appropriate for medicines and is appropriate for supplements when heavy metals are likely or certain to contaminate a given product. Setting reasonable health-based limits for some of these metals is challenging because of their ubiquity in the environment, limitations of current analytical procedures, and other factors. Taken together, compendial tests for metals in food and drugs present an array of issues that challenge compendial scientists.
Authors:
Darrell R Abernethy; Anthony J Destefano; Todd L Cecil; Kahkashan Zaidi; Roger L Williams;
Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-09
Journal Detail:
Title:  Pharmaceutical research     Volume:  27     ISSN:  1573-904X     ISO Abbreviation:  Pharm. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  750-5     Citation Subset:  IM    
Affiliation:
Documentary Standards Division, US Pharmacopeia, Rockville, Maryland 20852-1790, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemistry, Pharmaceutical
Drug Contamination*
Food Analysis
Food Contamination / analysis*
Humans
Metals / analysis*,  toxicity
Pharmacopoeias as Topic
Threshold Limit Values
Chemical
Reg. No./Substance:
0/Metals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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