| Metal impurities in food and drugs. | |
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MedLine Citation:
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PMID: 20217462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The major metals of potential health concern found in food, drugs (medicines), and dietary supplements are lead, cadmium, mercury, and arsenic. Other metals, such as chromium, copper, manganese, molybdenum, vanadium, nickel, osmium, rhodium, ruthenium, iridium, palladium, and platinum, may be used or introduced during manufacturing and may be controlled in the final article as impurities. Screening for metals in medicines and dietary supplements rarely indicates the presence of toxic metal impurities at levels of concern. The setting of heavy metal limits is appropriate for medicines and is appropriate for supplements when heavy metals are likely or certain to contaminate a given product. Setting reasonable health-based limits for some of these metals is challenging because of their ubiquity in the environment, limitations of current analytical procedures, and other factors. Taken together, compendial tests for metals in food and drugs present an array of issues that challenge compendial scientists. |
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Authors:
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Darrell R Abernethy; Anthony J Destefano; Todd L Cecil; Kahkashan Zaidi; Roger L Williams; |
Publication Detail:
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Type: Journal Article; Review Date: 2010-03-09 |
Journal Detail:
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Title: Pharmaceutical research Volume: 27 ISSN: 1573-904X ISO Abbreviation: Pharm. Res. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: United States |
Other Details:
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Languages: eng Pagination: 750-5 Citation Subset: IM |
Affiliation:
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Documentary Standards Division, US Pharmacopeia, Rockville, Maryland 20852-1790, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Pharmaceutical Drug Contamination* Food Analysis Food Contamination / analysis* Humans Metals / analysis*, toxicity Pharmacopoeias as Topic Threshold Limit Values |
| Chemical | |
Reg. No./Substance:
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0/Metals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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