Document Detail


[Metagenomics of the intestinal microbiota: potential applications].
MedLine Citation:
PMID:  20889001     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
A major challenge in the human metagenomics field is to identify associations of the bacterial genes and human phenotypes and act to modulate microbial populations in order to improve human health and wellbeing. MetaHIT project addresses this ambitious challenge by developing and integrating a number of necessary approaches within the context of the gut microbiome. Among the first results is the establishment of a broad catalog of the human gut microbial genes, which was achieved by an original application of the new generation sequencing technology. The catalog contains 3.3 million non-redundant genes, 150-fold more than the human genome equivalent and includes a large majority of the gut metagenomic sequences determined across three continents, Europe, America and Asia. Its content corresponds to some 1000 bacterial species, which likely represent a large fraction of species associated with humankind intestinal tract. The catalog enables development of the gene profiling approaches aiming to detect associations of bacterial genes and phenotypes. These should lead to the speedy development of diagnostic and prognostic tools and open avenues to reasoned approaches to the modulation of the individual's microbiota in order to optimize health and well-being.
Authors:
S Dusko Ehrlich;
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Gastroentérologie clinique et biologique     Volume:  34 Suppl 1     ISSN:  2210-7401     ISO Abbreviation:  Gastroenterol. Clin. Biol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704825     Medline TA:  Gastroenterol Clin Biol     Country:  France    
Other Details:
Languages:  fre     Pagination:  S23-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
Affiliation:
Institut National de la Recherche Agronomique, MetaHIT coordinator, Microbiology and the Food Chain Division, Jouy-en-Josas, France. dusko.ehrlich@jouy.inra.fr
Vernacular Title:
Métagénomique du microbiote intestinal: les applications potentielles.
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Investigator
Investigator/Affiliation:
Maria Antolin / ; François Artiguenave / ; Manimozhiyan Arumugam / ; Jean-Michel Batto / ; Marcelo Bertalan / ; Hervé Blottiere / ; Peer Bork / ; Natalia Borruel / ; Christian Brechot / ; Søren Brunak / ; Thomas Bruls / ; Kristoffer Solvsten Burgdorf / ; Jianjun Cao / ; Francesc Casellas / ; Christian Chervaux / ; Jean-Frederic Colombel / ; Antonella Cultrone / ; Joel Doré / ; Christine Delorme / ; Gérard Denariaz / ; Rozenn Dervyn / ; Miguel Forte / ; Carsten Friss / ; Francisco Guarner / ; Maarten van de Guchte / ; Eric Guedon / ; Florence Haimet / ; Torben Hansen / ; Alexandre Jamet / ; Min Jian / ; Catherine Juste / ; Ghalia Kaci / ; Michiel Kleerebezem / ; Jan Knol / ; Karsten Kristiansen / ; Severine Layec / ; Karine Le Roux / ; Marion Leclerc / ; Denis Le Paslier / ; Florence Levenez / ; Dongfang Li / ; Junhua Li / ; Shaochuan Li / ; Shengteng Li / ; Songgang Li / ; Yingrui Li / ; Huiqing Liang / ; Daniel Mende / ; Emmanuelle Maguin / ; Chaysavanh Manichanh / ; Raquel Melo Minardi / ; Christine Mrini / ; H Bjørn Nielsen / ; Trine Nielsen / ; Raish Oozeer / ; Julian Parkhill / ; Nicolas Pons / ; Oluf Pedersen / ; Eric Pelletier / ; Junjie Qin / ; Jeroen Raes / ; Pierre Renault / ; Maria Rescigno / ; Li Ruiqiang / ; Nicolas Sanchez / ; Thomas Sicheritz-Ponten / ; Sebastian Tims / ; Toni Torrejon / ; Keith Turner / ; Encarna Varela / ; Willem de Vos / ; Bo Wang / ; Jian Wang / ; Jun Wang / ; Jean Weissenbach / ; Yohanan Winogradsky / ; Yinlong Xie / ; Junming Xu / ; Takuji Yamada / ; Huanming Yang / ; Chang Yu / ; Xiuqing Zhang / ; Huisong Zheng / ; Hongmei Zhu / ; Yan Zhou / ; Erwin Zoetendal /

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