| Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. | |
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MedLine Citation:
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PMID: 21371176 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The epithelial-mesenchymal transition (EMT) is a process in which polarized epithelial cells are converted into motile mesenchymal cells. During cancer development, EMT is conducive to tumor dissemination and metastatic spread. While, overexpression of MTDH in breast cancer cell lines and tissues has been found to be associated with aggressive tumor behavior, its precise role in invasion and metastasis is largely unknown. Here we report that MTDH overexpression could significantly enhance the invasion and migration of breast cancer cells by inducing epithelial-mesenchymal transition. MTDH overexpression led to an upregulation of mesenchymal marker fibronectin, a downregulation of epithelial marker E-cadherin, and the nuclear accumulation of beta-catenin. Also, transcription factors Snail and Slug were up-regulated in breast cancer cells overexpressing MTDH. Overexpression of MTDH enhanced the invasiveness and the migration ability breast cancer cells in vitro. In addition, overexpression of MTDH led to an increased acquisition of CD44(+) /CD24(-/low) markers that are characteristic of breast cancer stem cells. We also showed that NF-kappa was involved in the expression of EMT-related markers. Taken together, our results suggest that MTDH could promote epithelial-mesenchymal transition in breast cancer cells in driving the progression of their aggressive behavior. |
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Authors:
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Xiaoyan Li; Xiaoli Kong; Qiang Huo; Haiyang Guo; Shi Yan; Cunzhong Yuan; Meena S Moran; Changshun Shao; Qifeng Yang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-3 |
Journal Detail:
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Title: Cancer science Volume: - ISSN: 1349-7006 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Japanese Cancer Association. |
Affiliation:
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Department of Breast Surgery Obstetrics and Gynecology, Qilu Hospital, Shandong University, School of Medicine, West Wenhua Road No. 107, Ji'nan, Shandong 250012, P. R. China Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, U.S.A. Institute of Molecular Medicine and Genetics and Key Laboratory of Experimental Teratology, Ministry of Education, Shandong University School of Medicine, Jinan, Shandong 250012. |
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