| Metacarpophalangeal pattern profile analysis in fragile X syndrome. | |
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MedLine Citation:
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PMID: 3239565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analyzed the metacarpophalangeal pattern profile (MCPP) on 18 male individuals from 16 families with fragile X--fra (X), or Martin-Bell--syndrome and calculated a mean syndrome profile. Fourteen of 18 individuals with fra (X) syndrome had significant positive correlations which indicated clinical homogeneity. Discriminant analysis of individuals with fra (X) syndrome compared with a sample of normal individuals produced a correct classification rate of 88% based on a function of 3 MCPP variables that may provide a useful tool in screening individuals for the fra (X) syndrome. Discriminant and correlation analyses of individuals with Sotos sequence and individuals with fra (X) syndrome did not identify MCPP similarities. Therefore, there was no MCPP evidence in our study of patients with Sotos sequence and fra (X) chromosome expression. |
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Authors:
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M G Butler; M Fletcher; D D Gale; F J Meaney; D R McLeod; J Fagan; N J Carpenter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of medical genetics Volume: 31 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-05-05 Completed Date: 1989-05-05 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 767-73 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Finger Joint / radiography* Fragile X Syndrome / radiography* Genetic Testing Humans Male Metacarpophalangeal Joint / radiography* Probability Sex Chromosome Aberrations / radiography* |
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