| Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats. | |
| | |
MedLine Citation:
|
PMID: 21896278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Systemic administration of the mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) was previously shown to selectively attenuate nicotine self-administration without affecting food-maintained responding in rats. Glutamatergic neurotransmission in the ventral tegmental area (VTA) and nucleus accumbens (NAcc) shell plays an important role in the reinforcing effects of nicotine. To determine the brain sites that may mediate the systemic effects of MPEP on nicotine self-administration, the present study investigated the effects of MPEP microinfusions into the VTA or the NAcc shell on nicotine and food self-administration in separate groups of rats. Administration of low MPEP doses (0, 0.5, 1, and 2 μg/0.5 μl/side) microinfused into the NAcc shell had no effect on nicotine self-administration, whereas higher MPEP doses (0, 10, 20, and 40 μg/0.5 μl/side) microinfused into the NAcc shell dose-dependently attenuated nicotine self-administration without affecting food-maintained responding. Microinfusions of MPEP into the VTA (0, 10, 20, and 40 μg/0.5 μl/side) significantly decreased both nicotine and food self-administration at 20 μg/0.5 μl/side but did not affect responding for either reinforcer at 40μg/0.5 μl/side. This lack of effect of 40 μg/0.5 μl/side MPEP on either nicotine or food self-administration when administered into the VTA may be attributable either to actions of MPEP at presynaptic mGlu5 receptors or at targets other than mGlu5 receptors. Importantly, anatomical control injections 2mm above the NAcc shell or the VTA using the most effective MPEP dose in the two regions did not result in attenuation of nicotine self-administration. In conclusion, MPEP microinfusions in the VTA or NAcc shell attenuates the reinforcing effects of nicotine possibly via blockade of mGlu5 receptors located in these regions. |
| | |
Authors:
|
Manoranjan S D'Souza; Athina Markou |
Related Documents
:
|
19210348 - Micro-arrayed wheat seed and grass pollen allergens for component-resolved diagnosis. 3789328 - Birch pollen asthma in the netherlands. 19557818 - Aspects of food processing and its effect on allergen structure. 17955998 - Application of current allergy assessment guidelines to next-generation biotechnology-d... 15209108 - Virulence reaction norms across a food gradient. 15202988 - Influence of the fight bac! food safety campaign on an urban latino population in conne... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-08-31 |
Journal Detail:
|
Title: Neuropharmacology Volume: 61 ISSN: 1873-7064 ISO Abbreviation: Neuropharmacology Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-10-07 Completed Date: 2012-08-01 Revised Date: 2013-02-19 |
Medline Journal Info:
|
Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: England |
Other Details:
|
Languages: eng Pagination: 1399-405 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Conditioning, Operant / drug effects Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists / pharmacology* Food Preferences / drug effects Male Nicotine / administration & dosage* Nicotinic Agonists / administration & dosage* Nucleus Accumbens / drug effects*, physiology Pyridines / pharmacology* Rats Rats, Wistar Reinforcement (Psychology)* Reinforcement Schedule Self Administration Ventral Tegmental Area / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
1R01DA11946/DA/NIDA NIH HHS; R01 DA011946-11/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/6-methyl-2-(phenylethynyl)pyridine; 0/Excitatory Amino Acid Antagonists; 0/Nicotinic Agonists; 0/Pyridines; 54-11-5/Nicotine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Large interclone differences in melezitose secretion in the facultatively ant-tended black bean aphi...
Next Document: The role of lateral occipital face and object areas in the face inversion effect.