Document Detail

Metabonomics and population studies: age-related amino acids excretion and inferring networks through the study of urine samples in two Italian isolated populations.
MedLine Citation:
PMID:  19067108     Owner:  NLM     Status:  MEDLINE    
The study of two different Italian isolated populations was combined with a metabonomic approach to better understand tubular handling of amino acids. Levels of amino acids and metabolites have been analyzed by Nucleic Magnetic Resonance and expressed as ratio vs urinary creatinine concentration (mmol/mol). For most of the amino acids there is an age-related U shape pattern of excretion, with the peaks during childhood and old age, and a significant reduction in the adult age. Hierarchical cluster analysis has clearly identified three groups clustering the same amino acids: His, Thr and Ala (group one); Gly and Phe (group two) and a third larger one. Results have been further confirmed by factor and regression analysis, and used to confirm and, in some cases, infer new amino acids networks. As a matter of facts, the identification of strong evidences for clustering of urine excretion of several neutral amino acids suggests the predominant impact of relevant and common transporters.
Pio D'Adamo; Sheila Ulivi; Amerigo Beneduci; Gabriele Pontoni; Giovambattista Capasso; Carmela Lanzara; Gilberto Andrighetto; Uros Hladnik; Virginia Nunes; Manuel Palacin; Paolo Gasparini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-09
Journal Detail:
Title:  Amino acids     Volume:  38     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Medical Genetics, Department of Laboratory Medicine, Institute for Maternal and Child Health IRCCS-Burlo Garofolo, Trieste, Italy.
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MeSH Terms
Age Factors
Amino Acids / chemistry,  urine*
Child, Preschool
Middle Aged
Population Groups*
Rural Population
Young Adult
Reg. No./Substance:
0/Amino Acids

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