Document Detail


Metabonomics and population studies: age-related amino acids excretion and inferring networks through the study of urine samples in two Italian isolated populations.
MedLine Citation:
PMID:  19067108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study of two different Italian isolated populations was combined with a metabonomic approach to better understand tubular handling of amino acids. Levels of amino acids and metabolites have been analyzed by Nucleic Magnetic Resonance and expressed as ratio vs urinary creatinine concentration (mmol/mol). For most of the amino acids there is an age-related U shape pattern of excretion, with the peaks during childhood and old age, and a significant reduction in the adult age. Hierarchical cluster analysis has clearly identified three groups clustering the same amino acids: His, Thr and Ala (group one); Gly and Phe (group two) and a third larger one. Results have been further confirmed by factor and regression analysis, and used to confirm and, in some cases, infer new amino acids networks. As a matter of facts, the identification of strong evidences for clustering of urine excretion of several neutral amino acids suggests the predominant impact of relevant and common transporters.
Authors:
Pio D'Adamo; Sheila Ulivi; Amerigo Beneduci; Gabriele Pontoni; Giovambattista Capasso; Carmela Lanzara; Gilberto Andrighetto; Uros Hladnik; Virginia Nunes; Manuel Palacin; Paolo Gasparini
Related Documents :
15369838 - Lamprey parasitism of sharks and teleosts: high capacity urea excretion in an extant ve...
2496518 - Comparison of the antidotal efficacy of polyamincarboxylic acids (cdta and dtpa) with t...
17079718 - Active ammonia transport and excretory nitrogen metabolism in the climbing perch, anaba...
3594008 - Aminoglycosides and renal acid excretion.
2605488 - Cerebral cortical concentrations of bioamines and their metabolites during arousal and ...
7889858 - Species differences in metabolism of heterocyclic aromatic amines, human exposure, and ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-09
Journal Detail:
Title:  Amino acids     Volume:  38     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Affiliation:
Medical Genetics, Department of Laboratory Medicine, Institute for Maternal and Child Health IRCCS-Burlo Garofolo, Trieste, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Amino Acids / chemistry,  urine*
Child
Child, Preschool
Female
Humans
Italy
Male
Metabolomics*
Middle Aged
Population Groups*
Rural Population
Young Adult
Chemical
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis, characterization and hybridization studies of an alternate nucleo-epsilon/gamma-peptide: ...
Next Document:  Effect of disease activity and corticosteroids on serum levels of soluble endothelial cell protein C...