| Metabonomics and its role in amino acid nutrition research. | |
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MedLine Citation:
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PMID: 21622188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabonomics combines metabolic profiling and multivariate data analysis to facilitate the high-throughput analysis of metabolites in biological samples. This technique has been developed as a powerful analytical tool and hence has found successful widespread applications in many areas of bioscience. Metabonomics has also become an important part of systems biology. As a sensitive and powerful method, metabonomics can quantitatively measure subtle dynamic perturbations of metabolic pathways in organisms due to changes in pathophysiological, nutritional, and epigenetic states. Therefore, metabonomics holds great promise to enhance our understanding of the complex relationship between amino acids and metabolism to define the roles for dietary amino acids in maintaining health and the development of disease. Such a technique also aids in the studies of functions, metabolic regulation, safety, and individualized requirements of amino acids. Here, we highlight the common workflow of metabonomics and some of the applications to amino acid nutrition research to illustrate the great potential of this exciting new frontier in bioscience. |
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Authors:
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Qinghua He; Yulong Yin; Feng Zhao; Xiangfeng Kong; Guoyao Wu; Pingping Ren |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-06-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 16 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-30 Completed Date: 2011-10-03 Revised Date: 2012-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 2451-60 Citation Subset: IM |
Affiliation:
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Research Center for Healthy Breeding of Livestock and Poultry, Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha, Hunan, China 410125. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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administration & dosage,
metabolism*,
toxicity Animals Diet Epigenesis, Genetic Humans Metabolome Metabolomics* Nutrigenomics Nutritional Physiological Phenomena* Nutritional Requirements Systems Biology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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