Document Detail


Metabonomics and its role in amino acid nutrition research.
MedLine Citation:
PMID:  21622188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metabonomics combines metabolic profiling and multivariate data analysis to facilitate the high-throughput analysis of metabolites in biological samples. This technique has been developed as a powerful analytical tool and hence has found successful widespread applications in many areas of bioscience. Metabonomics has also become an important part of systems biology. As a sensitive and powerful method, metabonomics can quantitatively measure subtle dynamic perturbations of metabolic pathways in organisms due to changes in pathophysiological, nutritional, and epigenetic states. Therefore, metabonomics holds great promise to enhance our understanding of the complex relationship between amino acids and metabolism to define the roles for dietary amino acids in maintaining health and the development of disease. Such a technique also aids in the studies of functions, metabolic regulation, safety, and individualized requirements of amino acids. Here, we highlight the common workflow of metabonomics and some of the applications to amino acid nutrition research to illustrate the great potential of this exciting new frontier in bioscience.
Authors:
Qinghua He; Yulong Yin; Feng Zhao; Xiangfeng Kong; Guoyao Wu; Pingping Ren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-06-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  16     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-30     Completed Date:  2011-10-03     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2451-60     Citation Subset:  IM    
Affiliation:
Research Center for Healthy Breeding of Livestock and Poultry, Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha, Hunan, China 410125.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / administration & dosage,  metabolism*,  toxicity
Animals
Diet
Epigenesis, Genetic
Humans
Metabolome
Metabolomics*
Nutrigenomics
Nutritional Physiological Phenomena*
Nutritional Requirements
Systems Biology
Chemical
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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