| Metabonomics in toxicology: a review. | |
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MedLine Citation:
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PMID: 15689416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabonomics and its many pseudonyms (metabolomics, metabolic profiling, etc.) have exploded onto the scientific scene in the past 2 to 3 years. Nowhere has the impact been more profound than within the toxicology community. Within this community there exists a great deal of uncertainty about whether metabonomics is something to count on or just the most recent technological flash in the pan. Much of the uncertainty is due to unfamiliarity with analytical and chemometric facets of the technology and the attendant fear of any "black-box." With those fears in mind, metabonomics technology is reviewed with particular emphasis on toxicologic applications in preclinical drug development. The jargon, logistics, and applications of the technology are covered in some detail with emphasis on recent work in the field. |
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Authors:
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Donald G Robertson |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-02-02 |
Journal Detail:
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Title: Toxicological sciences : an official journal of the Society of Toxicology Volume: 85 ISSN: 1096-6080 ISO Abbreviation: Toxicol. Sci. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-18 Completed Date: 2005-08-18 Revised Date: 2010-09-17 |
Medline Journal Info:
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Nlm Unique ID: 9805461 Medline TA: Toxicol Sci Country: United States |
Other Details:
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Languages: eng Pagination: 809-22 Citation Subset: IM |
Affiliation:
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Metabonomics Evaluation Group, Department of World-Wide Safety Sciences, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA. donald.robertson@pfizer.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers Chemical Phenomena Chemistry Guinea Pigs Magnetic Resonance Spectroscopy Metabolism / physiology* Robotics Terminology as Topic Toxicology / trends* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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