| Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence. | |
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MedLine Citation:
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PMID: 20812204 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Nutritional intervention is effective in reducing the risk of neural tube defects (NTDs). To determine the effects of nutritional supplementation on human metabolism, a metabonomic study was carried out on 96 women of reproductive age. Subjects with nutritional intervention were given fortified wheat flour (containing folic acid, vitamin B(1) , vitamin B(2) , ferric sodium edetate and zinc oxide) for 8 months. Serum metabolic fingerprinting was detected via ultraperformance liquid chromatography in tandem with time-of-flight mass spectrometry (UPLC-TOF MS), and data acquired was processed by multivariate statistical analysis. The result revealed a significant difference between the control and intervention group. Twenty potential biomarkers, including fructose 6-phosphate, sphingosine 1-phosphate, docosahexaenoic acid and hexadecanoic acid, were located and identified by the accurate mass measurement of TOF MS. These compounds are believed to be functionally related to anti-oxidative competence in vivo. In conclusion, metabonomics study is a valuable approach in exploring the effect mechanism of nutritional intervention on NTD prevention. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Zhiting Jiang; Qionglin Liang; Yong Wang; Xiaoying Zheng; Lijun Pei; Ting Zhang; Yiming Wang; Guoan Luo |
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Publication Detail:
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Type: Journal Article Date: 2010-09-01 |
Journal Detail:
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Title: Biomedical chromatography : BMC Volume: 25 ISSN: 1099-0801 ISO Abbreviation: Biomed. Chromatogr. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610241 Medline TA: Biomed Chromatogr Country: England |
Other Details:
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Languages: eng Pagination: 767-74 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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School of Pharmacy, East-China University of Science and Technology, Shanghai, 200237, People's Republic of China; Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, People's Republic of China. |
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