Document Detail


Metabonomic studies of schizophrenia and psychotropic medications: focus on alterations in CNS energy homeostasis.
MedLine Citation:
PMID:  21083107     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Schizophrenia is a severe neuropsychiatric disorder with a poorly understood etiology and progression. We and other research groups have found that energy metabolic pathways in the CNS are perturbed in many subjects with this disorder. Antipsychotic drugs that generally target neurotransmission are currently used for clinical management of the disorder, although these can also have marked effects on energy metabolism in the CNS and periphery. Recent proteomic and metabonomic studies have shown that molecular pathways associated with brain energy metabolism are altered in both the disorder and by antipsychotic treatments. This review focuses on discussion of these molecular alterations. Increased knowledge in this area could facilitate biomarker identification and drug discovery based on improving brain energy metabolism in this debilitating disorder.
Authors:
Dan Ma; Paul C Guest; Sabine Bahn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioanalysis     Volume:  1     ISSN:  1757-6199     ISO Abbreviation:  Bioanalysis     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101512484     Medline TA:  Bioanalysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1615-26     Citation Subset:  IM    
Affiliation:
Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK. dm250@cam.ac.uk
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