| Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits. | |
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MedLine Citation:
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PMID: 20676218 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Impaired glucose tolerance (IGT) which precedes overt type 2 diabetes (T2DM) for decades is associated with multiple metabolic alterations in insulin sensitive tissues. In an UPLC-qTOF-mass spectrometry-driven non-targeted metabonomics approach we investigated plasma as well as spot urine of 51 non-diabetic, overnight fasted individuals aiming to separate subjects with IGT from controls thereby identify pathways affected by the pre-diabetic metabolic state. We could clearly demonstrate that normal glucose tolerant (NGT) and IGT subjects clustered in two distinct groups independent of the investigated metabonome. These findings reflect considerable differences in individual metabolite fingerprints, both in plasma and urine. Pre-diabetes associated alterations in fatty acid-, tryptophan-, uric acid-, bile acid-, and lysophosphatidylcholine-metabolism, as well as the TCA cycle were identified. Of note, individuals with IGT also showed decreased levels of gut flora-associated metabolites namely hippuric acid, methylxanthine, methyluric acid, and 3-hydroxyhippuric acid. The findings of our non-targeted UPLC-qTOF-MS metabonomics analysis in plasma and spot urine of individuals with IGT vs NGT offers novel insights into the metabolic alterations occurring in the long, asymptomatic period preceding the manifestation of T2DM thereby giving prospects for new intervention targets. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11306-010-0203-1) contains supplementary material, which is available to authorized users. |
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Authors:
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Xinjie Zhao; Jens Fritsche; Jiangshan Wang; Jing Chen; Kilian Rittig; Philippe Schmitt-Kopplin; Andreas Fritsche; Hans-Ulrich Häring; Erwin D Schleicher; Guowang Xu; Rainer Lehmann |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-3-7 |
Journal Detail:
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Title: Metabolomics : Official journal of the Metabolomic Society Volume: 6 ISSN: 1573-3890 ISO Abbreviation: - Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-8-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274889 Medline TA: Metabolomics Country: - |
Other Details:
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Languages: ENG Pagination: 362-374 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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