Document Detail


Metabonomic characterization of early atherosclerosis in hamsters with induced cholesterol.
MedLine Citation:
PMID:  19552617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis is a complicated and multifactorial disease, induced not only by genotype, but also, even more importantly, by environmental factors. Study on the metabolic perturbation of endogenous compounds may offer deeper insight into development of atherosclerosis. Gas chromatography/mass spectrometry (GC/MS)-based metabonomics was used to profile a metabolic fingerprint of serum obtained from hamsters with induced cholesterol. The deconvoluted GC/MS data were processed by multivariate statistical analysis tools, such as principal component analysis (PCA) and partial least squares projection to latent structure and discriminant analysis (PLS-DA). For the first time we showed a time-dependent development of the model animal from normal to hypercholesterolaemia, and further to early atherosclerosis. Twenty-one compounds were identified as markers involved in the development to atherosclerosis. Identification of the compounds suggests that amino acid metabolism and fatty acid oxidation are significantly perturbed following cholesterol overloading. The data provide novel information to approach the pathophysiological processes of the hypercholesterolaemia and atherosclerosis disease continuum.
Authors:
Weibin Zha; Jiye A; Guangji Wang; Bei Yan; Shenghua Gu; Xuanxuan Zhu; Haiping Hao; Qing Huang; Jianguo Sun; Ying Zhang; Bei Cao; Hongcan Ren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  14     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  372-80     Citation Subset:  IM    
Affiliation:
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism
Animals
Atherosclerosis / etiology,  metabolism*
Cholesterol / metabolism*
Cricetinae
Fatty Acids / metabolism
Gas Chromatography-Mass Spectrometry
Hypercholesterolemia / metabolism
Metabolomics
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Fatty Acids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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