Document Detail


A metabonomic comparison of urinary changes in Zucker and GK rats.
MedLine Citation:
PMID:  20981252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To further investigate pathogenesis and pathogenic process of type 2 diabetes mellitus (T2DM), we compared the urinary metabolic profiling of Zucker obese and Goto-kakizaki (GK) rats by NMR-based metabonomics. Principal component analysis (PCA) on urine samples of both models rats indicates markedly elevated levels of creatine/creatinine, dimethylamine, and acetoacetate, with concomitantly declined levels of citrate, 2-ketoglurarate, lactate, hippurate, and succinate compared with control rats, respectively. Simultaneously, compared with Zucker obese rats, the GK rats show decreased levels of trimethylamine, acetate, and choline, as well as increased levels of creatine/creatinine, acetoacetate, alanine, citrate, 2-ketoglutarate, succinate, lactate, and hippurate. This study demonstrates metabolic similarities between the two stages of T2DM, including reduced tricarboxylic acid (TCA) cycle and increased ketone bodies production. In addition, compared with Zucker obese rats, the GK rats have enhanced concentration of energy metabolites, which indicates energy metabolic changes produced in hyperglycemia stage more than in insulin resistance stage.
Authors:
Liang-Cai Zhao; Xiao-Dong Zhang; Shi-Xian Liao; Hong-Chang Gao; He-Yao Wang; Dong-Hai Lin
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-13
Journal Detail:
Title:  Journal of biomedicine & biotechnology     Volume:  2010     ISSN:  1110-7251     ISO Abbreviation:  J. Biomed. Biotechnol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-28     Completed Date:  2011-02-17     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101135740     Medline TA:  J Biomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  431894     Citation Subset:  IM    
Affiliation:
Shanghai Institute of Materia Medica, The Chinese Academy of Sciences, Shanghai 201203, China.
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MeSH Terms
Descriptor/Qualifier:
Acids, Acyclic / urine
Animals
Biological Markers / urine*
Creatine / urine
Diabetes Mellitus, Type 2 / genetics,  physiopathology*,  urine*
Dimethylamines / urine
Disease Models, Animal*
Hippurates / urine
Hyperglycemia / physiopathology,  urine
Insulin Resistance / physiology*
Ketone Bodies / biosynthesis,  urine
Magnetic Resonance Spectroscopy
Male
Metabolomics*
Multivariate Analysis
Obesity / metabolism,  physiopathology
Rats
Rats, Wistar
Rats, Zucker
Species Specificity
Taurine / urine
Chemical
Reg. No./Substance:
0/Acids, Acyclic; 0/Biological Markers; 0/Dimethylamines; 0/Hippurates; 0/Ketone Bodies; 107-35-7/Taurine; 57-00-1/Creatine; ARQ8157E0Q/dimethylamine; TE0865N2ET/hippuric acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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