| A Metabonomic Characterization of (+)-Usnic Acid-Induced Liver Injury by Gas Chromatography-Mass Spectrometry-Based Metabolic Profiling of the Plasma and Liver in Rat. | |
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MedLine Citation:
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PMID: 21878557 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Three doses of (+)-usnic acid (100, 200, and 240 mg/kg per d) were administered orally to Wistar rats for 8 days, and metabonomic characterization of (+)-usnic acid-induced liver injury based on gas chromatography-mass spectrometry metabolic profiles was evaluated. Serum biochemical analysis and histopathological examinations were simultaneously performed. The liver/body weight ratio was significantly increased in (+)-usnic acid-treated groups, whereas serum alanine aminotransferase and total bilirubin were significantly elevated. In liver sections of 200 and 240 mg/kg dosage groups, widespread hydropic degeneration of hepatocytes was observed. Clusters in partial least squares discriminant analysis score plots showed control and (+)-usnic acid-treated groups had an obvious separation. (+)-Usnic acid exposure can lead to disturbances in energy metabolism, amino acid metabolism, lipid metabolism, and nucleotide metabolism, which may be attributable to (+)-usnic acid toxicological effects on the liver through oxidative stress. The significant changes in 22 metabolites in liver might be adopted as potential biomarkers. |
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Authors:
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Xiaoyan Lu; Qinqin Zhao; Yu Tian; Shun Xiao; Tingting Jin; Xiaohui Fan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-30 |
Journal Detail:
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Title: International journal of toxicology Volume: - ISSN: 1092-874X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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