Document Detail


Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes.
MedLine Citation:
PMID:  22048801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipid mediators derived from essential fatty acids, such as arachidonic acid, play important roles in physiologic and pathophysiologic processes. Prostaglandins, thromboxane, and leukotrienes are well-known eicosanoids that play critical roles in hemodynamics and inflammation. New families of mediators were recently uncovered that constitute a new genus stimulating resolution of acute inflammation, and are organ-protective. These include the resolvins (E-series and D-series), protectins (neuroprotectin D1/protectin D1), and maresins biosynthesized from omega-3 essential fatty acids. Phagocytes play major roles in tissue homeostasis and have a high capacity to produce these mediators, which depend on their tissue and state of activation. It is important to select appropriate methods for identifying target mediators and pathway biomarkers. In this unit, we review state-of-the-art approaches to identify and profile eicosanoid and docosanoid pathways, including specialized pro-resolving mediators resolvins, protectins, and maresins, in relation to their biosynthesis and inactivation by neutrophils and macrophages.
Authors:
Rong Yang; Nan Chiang; Sungwhan F Oh; Charles N Serhan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Current protocols in immunology / edited by John E. Coligan ... [et al.]     Volume:  Chapter 14     ISSN:  1934-368X     ISO Abbreviation:  Curr Protoc Immunol     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-03     Completed Date:  2012-02-21     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9101651     Medline TA:  Curr Protoc Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  Unit 14.26     Citation Subset:  IM    
Affiliation:
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, High Pressure Liquid
Docosahexaenoic Acids / immunology*
Eicosanoids / immunology*
Humans
Metabolomics
Phagocytes / immunology*
Tandem Mass Spectrometry
Grant Support
ID/Acronym/Agency:
GM38765/GM/NIGMS NIH HHS; P01 GM095467-01/GM/NIGMS NIH HHS; R01 DE019938-03/DE/NIDCR NIH HHS; R01 DE019938-04/DE/NIDCR NIH HHS; R01 GM038765-24/GM/NIGMS NIH HHS; R01 GM038765-25/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Eicosanoids; 25167-62-8/Docosahexaenoic Acids
Comments/Corrections

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