Document Detail


Metabolomics as a tool for cardiac research.
MedLine Citation:
PMID:  21931361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metabolomics represents a paradigm shift in metabolic research, away from approaches that focus on a limited number of enzymatic reactions or single pathways, to approaches that attempt to capture the complexity of metabolic networks. Additionally, the high-throughput nature of metabolomics makes it ideal to perform biomarker screens for diseases or follow drug efficacy. In this Review, we explore the role of metabolomics in gaining mechanistic insight into cardiac disease processes, and in the search for novel biomarkers. High-resolution NMR spectroscopy and mass spectrometry are both highly discriminatory for a range of pathological processes affecting the heart, including cardiac ischemia, myocardial infarction, and heart failure. We also discuss the position of metabolomics in the range of functional-genomic approaches, being complementary to proteomic and transcriptomic studies, and having subdivisions such as lipidomics (the study of intact lipid species). In addition to techniques that monitor changes in the total sizes of pools of metabolites in the heart and biofluids, the role of stable-isotope methods for monitoring fluxes through pathways is examined. The use of these novel functional-genomic tools to study metabolism provides a unique insight into cardiac disease progression.
Authors:
Julian L Griffin; Helen Atherton; John Shockcor; Luigi Atzori
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-20
Journal Detail:
Title:  Nature reviews. Cardiology     Volume:  8     ISSN:  1759-5010     ISO Abbreviation:  Nat Rev Cardiol     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-25     Completed Date:  2012-02-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101500075     Medline TA:  Nat Rev Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  630-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers
Biomedical Technology / trends
Cardiovascular Diseases / diagnosis*,  metabolism,  pathology
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Metabolic Networks and Pathways
Grant Support
ID/Acronym/Agency:
093,148/Z/10/Z//Wellcome Trust; BB/H013539/1//Biotechnology and Biological Sciences Research Council; G0801841//Department of Health; MC_UP_A090_1006//Medical Research Council
Chemical
Reg. No./Substance:
0/Biological Markers

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